A massive 7T fMRI dataset to bridge cognitive neuroscience and artificial intelligence

Emily J Allen, Ghislain St-Yves, Yihan Wu, Jesse L. Breedlove, Jacob S. Prince, Logan T. Dowdle, Matthias Nau, Brad Caron, Franco Pestilli, Ian Charest, J. Benjamin Hutchinson, Thomas Naselaris, Kendrick Kay

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Extensive sampling of neural activity during rich cognitive phenomena is critical for robust understanding of brain function. Here we present the Natural Scenes Dataset (NSD), in which high-resolution functional magnetic resonance imaging responses to tens of thousands of richly annotated natural scenes were measured while participants performed a continuous recognition task. To optimize data quality, we developed and applied novel estimation and denoising techniques. Simple visual inspections of the NSD data reveal clear representational transformations along the ventral visual pathway. Further exemplifying the inferential power of the dataset, we used NSD to build and train deep neural network models that predict brain activity more accurately than state-of-the-art models from computer vision. NSD also includes substantial resting-state and diffusion data, enabling network neuroscience perspectives to constrain and enhance models of perception and memory. Given its unprecedented scale, quality and breadth, NSD opens new avenues of inquiry in cognitive neuroscience and artificial intelligence.

Original languageEnglish (US)
Pages (from-to)116-126
Number of pages11
JournalNature neuroscience
Volume25
Issue number1
DOIs
StatePublished - Jan 2022

Bibliographical note

Funding Information:
We thank the NSD participants for their time and endurance; E. Aminoff, J. Pyles, M. Tarr, M. Hebart and C. Baker for advice on experimental design and data collection; J. Power and A. Schapiro for consultation on resting-state and physiological data; V. Carr and R. Olsen for consultation on hippocampal subfield scanning protocols; A. Grant for assistance with scanner peripherals; F. Gosselin and J. Tardif for contrast sensitivity analysis; B. Klimes-Dougan and K. Cullen for designing the valence/arousal assessment; W. Guo for segmentations of the medial temporal lobe; M. Arcaro, A. Bratch, D. Finzi, A. White and J. Winawer for assistance with ROI definition; C. Gorgolewski and R. Poldrack for discussion of BIDS and data sharing; R. Cichy, E. Yacoub, K. Grill-Spector, K. Jamison, A. Rokem, A. Huth, S. Anzellotti, N. Kriegeskorte and J. Winawer for general discussions; and K. Ugurbil for overall project advice. We also thank our NSD collaborators for shaping the trajectory of the project. This work was supported by NSF CRCNS grants IIS-1822683 (K.K.) and IIS-1822929 (T.N.); NIH grants P41 EB015894, P30 NS076408, S10 RR026783 and S10 OD017974-01, the W. M. Keck Foundation and the NIMH Intramural Research Program ZIAMH002909 (M.N.); and NSF BCS-1734853, NIH NIBIB R01EB030896, NIH NIBIB R01EB029272 and NIH IIS-1912270 (F.P.).

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.

Center for Magnetic Resonance Research (CMRR) tags

  • IRP
  • BFC

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, Non-P.H.S.

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