A LSO beta microprobe for measuring input functions for quantitative small animal PET

S. Maramraju, S. Stoll, C. Woody, D. Schlyer, Wynne K Schiffer, D. Lee, S. Dewey, P. Vaska

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

A miniature scintillation microprobe has been developed to measure the input function in live rodents for use in longitudinal, quantitative PET studies. The probe consists of a small lutetium oxyorthosilicate (LSO) crystal measuring typically 0.3-0.5 mm diameter x 0.5-2 mm in length that is used to directly detect positrons in the blood or tissue. The probe has a sensitivity of 10-40 Hz/μCi/cc and is primarily sensitive to short range positrons emitted by labeled radiotracers in the blood. The sensitivity to gamma-ray background can be minimized using a variable threshold in the readout to discriminate between positrons and gammas. The probe was implanted in one of the tail veins of a Sprague-Dawley rat and the input function was measured for the injection of 0.8 mCi of FDG in the other tail vein. The probe exhibits a fast time response that is able to quickly and accurately measure the concentration of 18F circulating in the bloodstream. This probe is shorter in length which makes the placement easier.

Original languageEnglish (US)
Title of host publication33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
Pages56-57
Number of pages2
DOIs
StatePublished - Dec 1 2007
Event33rd Annual Northeast Bioengineering Conference, NEBC - Stony Brook, NY, United States
Duration: Mar 10 2007Mar 11 2007

Publication series

NameBioengineering, Proceedings of the Northeast Conference
ISSN (Print)1071-121X

Other

Other33rd Annual Northeast Bioengineering Conference, NEBC
CountryUnited States
CityStony Brook, NY
Period3/10/073/11/07

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