A LSO beta microprobe for measuring input functions for quantitative small animal PET

S. Maramraju, S. Stoll, C. Woody, D. Schlyer, W. Schiffer, D. Lee, S. Dewey, P. Vaska

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

A miniature scintillation β microprobe has been developed to measure the input function in live rodents for use in longitudinal, quantitative PET studies. The probe consists of a small lutetium oxyorthosilicate (LSO) crystal measuring typically 0.3-0.6 mm diameter x 0.5-2 mm in length that is used to directly detect positrons in the blood or tissue. The probe has a sensitivity of 10-40 Hz/μCi/cc and is primarily sensitive to short range positrons emitted by labeled radiotracers in the blood. The sensitivity to gamma-ray background can be minimized using a variable threshold in the readout to discriminate between positrons and gammas. The probe was implanted in one of the tail veins of a Sprague-Dawley rat and the input function was measured for the injection of 0.8 mCi of FDG in the other tail vein. The probe exhibits a fast time response that is able to quickly and accurately measure the concentration of 18F circulating in the bloodstream. Additional tests were also carried out to study the probe's sensitivity to gamma ray background.

Original languageEnglish (US)
Title of host publication2006 IEEE Nuclear Science Symposium - Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2713-2716
Number of pages4
ISBN (Print)1424405610, 9781424405619
DOIs
StatePublished - Jan 1 2006
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: Oct 29 2006Nov 4 2006

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume5
ISSN (Print)1095-7863

Other

Other2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
CountryUnited States
CitySan Diego, CA
Period10/29/0611/4/06

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    Maramraju, S., Stoll, S., Woody, C., Schlyer, D., Schiffer, W., Lee, D., Dewey, S., & Vaska, P. (2006). A LSO beta microprobe for measuring input functions for quantitative small animal PET. In 2006 IEEE Nuclear Science Symposium - Conference Record (pp. 2713-2716). [4179597] (IEEE Nuclear Science Symposium Conference Record; Vol. 5). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2006.356440