A LSO β microprobe for measuring input functions for quantitative small animal PET

S. Maramraju; S. Stoll; C. Woody; D. Schlyer; W. Schiffer; D. Lee; S. Dewey; P. Vaska

doi:10.1016/j.nima.2006.10.121

A LSO β microprobe for measuring input functions for quantitative small animal PET

S. Maramraju, S. Stoll, C. Woody, D. Schlyer, W. Schiffer, D. Lee, S. Dewey, P. Vaska

Neurology

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Abstract

A miniature scintillation microprobe has been developed to measure the input function in live rodents for use in longitudinal, quantitative PET studies. The probe consists of a small lutetium oxyorthosilicate (LSO) crystal measuring typically 0.3-0.5 mm diameter ×0.5-2 mm in length that is used to directly detect positrons in the blood or tissue. The probe has a sensitivity of 10-30 Hz/μCi/cm³ and is primarily sensitive to short-range positrons emitted by labeled radiotracers in the blood. The sensitivity to γ-ray background can be minimized using a variable threshold in the readout to discriminate between positrons and γ's. The probe was implanted in one of the tail veins of a Sprague-Dawley rat and the input function was measured for the injection of 0.8 mCi of FDG in the other tail vein. The probe exhibits a fast time response that is able to quickly and accurately measure the concentration of ¹⁸F circulating in the bloodstream. Additional tests were also carried out to study the probe's sensitivity to γ-ray background.

Original language	English (US)
Pages (from-to)	407-410
Number of pages	4
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	571
Issue number	1-2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.nima.2006.10.121
State	Published - Feb 1 2007

Bibliographical note

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Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

Input function
LSO
Microprobe
Small animal PET

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10.1016/j.nima.2006.10.121

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Maramraju, S., Stoll, S., Woody, C., Schlyer, D., Schiffer, W., Lee, D., Dewey, S., & Vaska, P. (2007). A LSO β microprobe for measuring input functions for quantitative small animal PET. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 571(1-2 SPEC. ISS.), 407-410. https://doi.org/10.1016/j.nima.2006.10.121

A LSO β microprobe for measuring input functions for quantitative small animal PET. / Maramraju, S.; Stoll, S.; Woody, C. et al.
In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 571, No. 1-2 SPEC. ISS., 01.02.2007, p. 407-410.

Research output: Contribution to journal › Article › peer-review

Maramraju, S, Stoll, S, Woody, C, Schlyer, D, Schiffer, W, Lee, D, Dewey, S & Vaska, P 2007, 'A LSO β microprobe for measuring input functions for quantitative small animal PET', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 571, no. 1-2 SPEC. ISS., pp. 407-410. https://doi.org/10.1016/j.nima.2006.10.121

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A LSO β microprobe for measuring input functions for quantitative small animal PET

Abstract

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