A lack of μ-opioid receptors modulates the expressions of neuropeptide Y and substance P mRNA

Ji Hoon Yoo; Jae Han Cho; Seok Yong Lee; Horace H. Loh; Ing K. Ho; Choon Gon Jang

doi:10.1016/j.neulet.2005.04.046

A lack of μ-opioid receptors modulates the expressions of neuropeptide Y and substance P mRNA

Ji Hoon Yoo, Jae Han Cho, Seok Yong Lee, Horace H. Loh, Ing K. Ho, Choon Gon Jang

Pharmacology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The present study was undertaken to investigate changes in the expressions of neuropeptide Y (NPY) and substance P (SP) in mice lacking μ-opioid receptors. In an in situ hybridization study, in which we compared wild type and μ-opioid receptor knockout mice, NPY mRNA levels were found to be lower in the caudate-putamen and nucleus accumbens of μ-opioid receptor knockout mice. In addition, SP mRNA levels were lower in the ventromedial hypothalamic nucleus of μ-opioid receptor knockout mice. Our findings suggest that a lack of μ-opioid receptors modulates basal NPY mRNA levels in striatal regions and SP mRNA levels in the ventromedial hypothalamic nucleus of the mouse, and that these changes are due to compensatory modulation in the brain.

Original language	English (US)
Pages (from-to)	29-32
Number of pages	4
Journal	Neuroscience Letters
Volume	384
Issue number	1-2
DOIs	https://doi.org/10.1016/j.neulet.2005.04.046
State	Published - Aug 12 2005

Bibliographical note

Funding Information:
This research was supported by a grant (M103KV010008 05K2201 00830) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Republic of Korea.

Keywords

In situ hybridization
Neuropeptide Y
Substance P
μ-Opioid receptor knockout mice

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10.1016/j.neulet.2005.04.046

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abstract = "The present study was undertaken to investigate changes in the expressions of neuropeptide Y (NPY) and substance P (SP) in mice lacking μ-opioid receptors. In an in situ hybridization study, in which we compared wild type and μ-opioid receptor knockout mice, NPY mRNA levels were found to be lower in the caudate-putamen and nucleus accumbens of μ-opioid receptor knockout mice. In addition, SP mRNA levels were lower in the ventromedial hypothalamic nucleus of μ-opioid receptor knockout mice. Our findings suggest that a lack of μ-opioid receptors modulates basal NPY mRNA levels in striatal regions and SP mRNA levels in the ventromedial hypothalamic nucleus of the mouse, and that these changes are due to compensatory modulation in the brain.",

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note = "Funding Information: This research was supported by a grant (M103KV010008 05K2201 00830) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Republic of Korea.",

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AU - Yoo, Ji Hoon

AU - Cho, Jae Han

AU - Lee, Seok Yong

AU - Loh, Horace H.

AU - Ho, Ing K.

AU - Jang, Choon Gon

N1 - Funding Information: This research was supported by a grant (M103KV010008 05K2201 00830) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Republic of Korea.

PY - 2005/8/12

Y1 - 2005/8/12

N2 - The present study was undertaken to investigate changes in the expressions of neuropeptide Y (NPY) and substance P (SP) in mice lacking μ-opioid receptors. In an in situ hybridization study, in which we compared wild type and μ-opioid receptor knockout mice, NPY mRNA levels were found to be lower in the caudate-putamen and nucleus accumbens of μ-opioid receptor knockout mice. In addition, SP mRNA levels were lower in the ventromedial hypothalamic nucleus of μ-opioid receptor knockout mice. Our findings suggest that a lack of μ-opioid receptors modulates basal NPY mRNA levels in striatal regions and SP mRNA levels in the ventromedial hypothalamic nucleus of the mouse, and that these changes are due to compensatory modulation in the brain.

AB - The present study was undertaken to investigate changes in the expressions of neuropeptide Y (NPY) and substance P (SP) in mice lacking μ-opioid receptors. In an in situ hybridization study, in which we compared wild type and μ-opioid receptor knockout mice, NPY mRNA levels were found to be lower in the caudate-putamen and nucleus accumbens of μ-opioid receptor knockout mice. In addition, SP mRNA levels were lower in the ventromedial hypothalamic nucleus of μ-opioid receptor knockout mice. Our findings suggest that a lack of μ-opioid receptors modulates basal NPY mRNA levels in striatal regions and SP mRNA levels in the ventromedial hypothalamic nucleus of the mouse, and that these changes are due to compensatory modulation in the brain.

KW - In situ hybridization

KW - Neuropeptide Y

KW - Substance P

KW - μ-Opioid receptor knockout mice

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A lack of μ-opioid receptors modulates the expressions of neuropeptide Y and substance P mRNA

Abstract

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Keywords

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