A hypothesis for the molecular mechanism of tumor killing by porphyrins and light

D. A. Peterson; S. McKelvey; P. R. Edmondson

doi:10.1016/0306-9877(81)90116-X

A hypothesis for the molecular mechanism of tumor killing by porphyrins and light

D. A. Peterson, S. McKelvey, P. R. Edmondson

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Tumor cells have an absence or deficiency of mitochondrial superoxide dismutase. Superoxide is produced when hematoporphyrin derivative is exposed to visible light. A significant portion of the antitumor effect of porphyrin: light therapy is hypothesized to be mediated by superoxide.

Original language	English (US)
Pages (from-to)	201-205
Number of pages	5
Journal	Medical Hypotheses
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/0306-9877(81)90116-X
State	Published - Feb 1981

Bibliographical note

Funding Information:
We are most appreciative of the helpful comments of Dr. S. Schwartz. Drs. J.M. Gerrard, J.G. White, and G.H.R. Rao are also acknowledged. We also wish to thank Linda Richter, Jan De Lue, and Mary Jo Showalter for technical assistance. This work was partially supported by USPHS Grant AM12466 to S. Schwartz. Dr. Peterson is an established investigator of the West Duluth Research Foundation.

Keywords

Cancer
Light
Porphyrins
Superoxide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "A hypothesis for the molecular mechanism of tumor killing by porphyrins and light",

abstract = "Tumor cells have an absence or deficiency of mitochondrial superoxide dismutase. Superoxide is produced when hematoporphyrin derivative is exposed to visible light. A significant portion of the antitumor effect of porphyrin: light therapy is hypothesized to be mediated by superoxide.",

keywords = "Cancer, Light, Porphyrins, Superoxide",

author = "Peterson, {D. A.} and S. McKelvey and Edmondson, {P. R.}",

note = "Funding Information: We are most appreciative of the helpful comments of Dr. S. Schwartz. Drs. J.M. Gerrard, J.G. White, and G.H.R. Rao are also acknowledged. We also wish to thank Linda Richter, Jan De Lue, and Mary Jo Showalter for technical assistance. This work was partially supported by USPHS Grant AM12466 to S. Schwartz. Dr. Peterson is an established investigator of the West Duluth Research Foundation.",

year = "1981",

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doi = "10.1016/0306-9877(81)90116-X",

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T1 - A hypothesis for the molecular mechanism of tumor killing by porphyrins and light

AU - Peterson, D. A.

AU - McKelvey, S.

AU - Edmondson, P. R.

N1 - Funding Information: We are most appreciative of the helpful comments of Dr. S. Schwartz. Drs. J.M. Gerrard, J.G. White, and G.H.R. Rao are also acknowledged. We also wish to thank Linda Richter, Jan De Lue, and Mary Jo Showalter for technical assistance. This work was partially supported by USPHS Grant AM12466 to S. Schwartz. Dr. Peterson is an established investigator of the West Duluth Research Foundation.

PY - 1981/2

Y1 - 1981/2

N2 - Tumor cells have an absence or deficiency of mitochondrial superoxide dismutase. Superoxide is produced when hematoporphyrin derivative is exposed to visible light. A significant portion of the antitumor effect of porphyrin: light therapy is hypothesized to be mediated by superoxide.

AB - Tumor cells have an absence or deficiency of mitochondrial superoxide dismutase. Superoxide is produced when hematoporphyrin derivative is exposed to visible light. A significant portion of the antitumor effect of porphyrin: light therapy is hypothesized to be mediated by superoxide.

KW - Cancer

KW - Light

KW - Porphyrins

KW - Superoxide

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SN - 0306-9877

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JO - Medical Hypotheses

JF - Medical Hypotheses

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ER -

A hypothesis for the molecular mechanism of tumor killing by porphyrins and light

Abstract

Bibliographical note

Keywords

UN SDGs

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