A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery

Hongliang Cao, Chao Chen, Debiao Xie, Xin Chen, Ping Wang, Yibing Wang, Huajie Song, Wenxin Wang

Research output: Contribution to journalArticle

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Abstract

Nanoparticles are appealing drug delivery systems since they promise prolonged circulation time and predictable release behaviors. The current work reports a novel hyperbranched amphiphilic block copolymer synthesized using deactivation-enhanced atom transfer radical polymerization (DE-ATRP) for smart drug delivery. PEG2000-Br was applied as a macroinitiator to initiate acid-cleavable divinyl (ACD) monomers linked by acetal groups, formulating the hydrophilic (PEG) and hydrophobic (ACD) segments. The polymer appeared to self-assemble into micelles with diameters in the range of 70-100 nm, and was examined for the controlled release of doxorubicin (DOX). Results showed that DOX-loaded micelles (∼90 nm) could achieve drug loading as high as 8.2 wt%, with interesting pH-dependent release behaviors. Studies with flow cytometry (FCM) and confocal laser scanning microscopy (CLSM) showed that DOX-loaded micelles exhibited a high cellular uptake performance by HeLa cells, which indicated promising anti-tumor efficacy for such a drug delivery system. Additionally, such DOX-loaded micelles exhibited remarkable cytotoxicity against HeLa cells in a dose- and time-dependent manner due to the enhanced cell uptake behavior of micelles. These results indicated that the polymeric micelles might be used as a promising candidate for a pH-responsive drug delivery for cancer therapy.

LanguageEnglish (US)
Pages169-177
Number of pages9
JournalPolymer Chemistry
Volume9
Issue number2
DOIs
StatePublished - Jan 14 2018

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Acetals
Micelles
Drug delivery
Polymers
Doxorubicin
Pharmaceutical Preparations
Drug Delivery Systems
HeLa Cells
Acids
Flow cytometry
Atom transfer radical polymerization
Cytotoxicity
Confocal Microscopy
Polymerization
Nanoparticles
Polyethylene glycols
Block copolymers
Tumors
Neoplasms
Flow Cytometry

Cite this

Cao, H., Chen, C., Xie, D., Chen, X., Wang, P., Wang, Y., ... Wang, W. (2018). A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery. Polymer Chemistry, 9(2), 169-177. DOI: 10.1039/c7py01739a

A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery. / Cao, Hongliang; Chen, Chao; Xie, Debiao; Chen, Xin; Wang, Ping; Wang, Yibing; Song, Huajie; Wang, Wenxin.

In: Polymer Chemistry, Vol. 9, No. 2, 14.01.2018, p. 169-177.

Research output: Contribution to journalArticle

Cao, H, Chen, C, Xie, D, Chen, X, Wang, P, Wang, Y, Song, H & Wang, W 2018, 'A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery' Polymer Chemistry, vol. 9, no. 2, pp. 169-177. DOI: 10.1039/c7py01739a
Cao H, Chen C, Xie D, Chen X, Wang P, Wang Y et al. A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery. Polymer Chemistry. 2018 Jan 14;9(2):169-177. Available from, DOI: 10.1039/c7py01739a
Cao, Hongliang ; Chen, Chao ; Xie, Debiao ; Chen, Xin ; Wang, Ping ; Wang, Yibing ; Song, Huajie ; Wang, Wenxin. / A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery. In: Polymer Chemistry. 2018 ; Vol. 9, No. 2. pp. 169-177
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