Abstract
In this paper, we report on the fabrication and testing of a hydrogel-actuated smart microvalve for biomedical applications. The three-layered microvalve is composed of a stimuli-sensitive "intelligent" hydrogel sandwiched between a porous silicon membrane and a bossed PDMS flexible diaphragm. The entrapped hydrogel in response to changes in the external physiological stimuli (e.g., pH, glucose, etc.), which diffuses through the porous membrane, swelles and deswelles hence deflecting the flexible PDMS diaphragm and controlling the closure and opening of the microvalve inlet. A microvalve incorporating a 155μm thick hydrogel (poly(methacrylic acid-co-acrylamide), mAA-co-AAm) has a response time of 3. 6min to a sudden pH change (pH=3 to pH=7).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2041-2044 |
| Number of pages | 4 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 26 III |
| State | Published - 2004 |
| Event | Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States Duration: Sep 1 2004 → Sep 5 2004 |
Keywords
- Flow control
- Hydrogel
- Microfluidics
- Microvalve
- PDMS
- pH-sensitive