TY - JOUR
T1 - A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.
AU - Geraghty, D. E.
AU - Koller, B. H.
AU - Orr, H. T.
PY - 1987/12
Y1 - 1987/12
N2 - We have cloned genomic DNA encoding a non-HLA-A, -B, -C class I gene located within a HindIII-generated restriction fragment of 6.0 kilobase pairs. This gene, designated HLA-6.0, is as homologous to HLA-A and HLA-B as they are to each other. The HLA class I protein encoded by HLA-6.0 is similar in organization to the HLA-A-, -B-, and -C-encoded proteins except that an in-frame termination codon prevents translation of a majority of the cytoplasmic region of the HLA-6.0 polypeptide. Moreover, the promoter region of HLA-6.0 resembles the promoter region of a Qa region gene. These structural features of HLA-6.0 suggest that this non-HLA-A, -B, -C gene is a structural homolog of a murine Qa region class I gene.
AB - We have cloned genomic DNA encoding a non-HLA-A, -B, -C class I gene located within a HindIII-generated restriction fragment of 6.0 kilobase pairs. This gene, designated HLA-6.0, is as homologous to HLA-A and HLA-B as they are to each other. The HLA class I protein encoded by HLA-6.0 is similar in organization to the HLA-A-, -B-, and -C-encoded proteins except that an in-frame termination codon prevents translation of a majority of the cytoplasmic region of the HLA-6.0 polypeptide. Moreover, the promoter region of HLA-6.0 resembles the promoter region of a Qa region gene. These structural features of HLA-6.0 suggest that this non-HLA-A, -B, -C gene is a structural homolog of a murine Qa region class I gene.
UR - http://www.scopus.com/inward/record.url?scp=0023475627&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023475627&partnerID=8YFLogxK
U2 - 10.1073/pnas.84.24.9145
DO - 10.1073/pnas.84.24.9145
M3 - Article
C2 - 3480534
AN - SCOPUS:0023475627
SN - 0027-8424
VL - 84
SP - 9145
EP - 9149
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 24
ER -