A highly efficient synthesis of cyclaradine and its behaviour towards adenosine deaminase.

N. Katagiri, H. Kokufuda, M. Makino, Y. Matsuhashi, C. Kaneko, Robert Vince

Research output: Contribution to journalArticlepeer-review

Abstract

(+)-, (-)-, and (+/-)-Cyclaradines were efficiently synthesized from 2-aza-bicyclo[2.2.1]hept-5-en-3-one (ABH). (+)- and (+/-)-Cyclaradines were deaminated by adenosine deaminase whereas (-)-cyclaradine was not hydrolyzed under the same conditions.

Original languageEnglish (US)
Pages (from-to)3-4
Number of pages2
JournalNucleic acids symposium series
Issue number37
StatePublished - 1997
Externally publishedYes

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