A high-resolution amperometric acetylcholine biosensor based on nano self-assembly of carbon nanotubes

Wei Xue; Tianhong Cui

A high-resolution amperometric acetylcholine biosensor based on nano self-assembly of carbon nanotubes

Wei Xue, Tianhong Cui

Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

We present a carbon nanotube thin film based device as a high-resolution acetylcholine sensor. Carbon nanotube and acetylcholinesterase thin films are self-assembled on a silicon substrate as conducting and sensing layers, respectively. Both films are deposited using layer-by-layer self-assembly process. The conductance of the carbon nanotube film is changed due to the generated hydrogen ions in the acetylcholine solution. The resolution of the device is measured as 100 pM. Due to its high resolution, small size, and low cost, the carbon nanotube biosensor has tremendous potential for applications to medical research and clinical diagnosis.

Original language	English (US)
Title of host publication	Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007
Pages	529-532
Number of pages	4
State	Published - 2007
Event	20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007 - Kobe, Japan Duration: Jan 21 2007 → Jan 25 2007

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Other

Other	20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007
Country/Territory	Japan
City	Kobe
Period	1/21/07 → 1/25/07

Keywords

Acetylcholine (ACh)
Biosensor
Carbon nanotubes (CNTs)
Layer-by-layer (LbL) self-assembly

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Xue, W., & Cui, T. (2007). A high-resolution amperometric acetylcholine biosensor based on nano self-assembly of carbon nanotubes. In Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007 (pp. 529-532). Article 4433151 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

A high-resolution amperometric acetylcholine biosensor based on nano self-assembly of carbon nanotubes. / Xue, Wei; Cui, Tianhong.
Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007. 2007. p. 529-532 4433151 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Xue, W & Cui, T 2007, A high-resolution amperometric acetylcholine biosensor based on nano self-assembly of carbon nanotubes. in Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007., 4433151, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 529-532, 20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007, Kobe, Japan, 1/21/07.

Xue W, Cui T. A high-resolution amperometric acetylcholine biosensor based on nano self-assembly of carbon nanotubes. In Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007. 2007. p. 529-532. 4433151. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Xue, Wei ; Cui, Tianhong. / A high-resolution amperometric acetylcholine biosensor based on nano self-assembly of carbon nanotubes. Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007. 2007. pp. 529-532 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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abstract = "We present a carbon nanotube thin film based device as a high-resolution acetylcholine sensor. Carbon nanotube and acetylcholinesterase thin films are self-assembled on a silicon substrate as conducting and sensing layers, respectively. Both films are deposited using layer-by-layer self-assembly process. The conductance of the carbon nanotube film is changed due to the generated hydrogen ions in the acetylcholine solution. The resolution of the device is measured as 100 pM. Due to its high resolution, small size, and low cost, the carbon nanotube biosensor has tremendous potential for applications to medical research and clinical diagnosis.",

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AB - We present a carbon nanotube thin film based device as a high-resolution acetylcholine sensor. Carbon nanotube and acetylcholinesterase thin films are self-assembled on a silicon substrate as conducting and sensing layers, respectively. Both films are deposited using layer-by-layer self-assembly process. The conductance of the carbon nanotube film is changed due to the generated hydrogen ions in the acetylcholine solution. The resolution of the device is measured as 100 pM. Due to its high resolution, small size, and low cost, the carbon nanotube biosensor has tremendous potential for applications to medical research and clinical diagnosis.

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KW - Layer-by-layer (LbL) self-assembly

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A high-resolution amperometric acetylcholine biosensor based on nano self-assembly of carbon nanotubes

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