A Haemocyte tropism for an arbovirus

Grishma R. Parikh, Jonathan D. Oliver, Lyric C. Bartholomay

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Horizontally transmitted mosquito-borne viruses enter the midgut with a blood meal then disseminate to infect the salivary glands. En route to the salivary glands, these viruses encounter the plasma (haemolymph) and blood cells (haemocytes). Haemocytes respond to a variety of micro-organisms, but their role in virus replication and dissemination has not been described. To look for a potential haemocyte tropism for an arbovirus, a Sindbis virus was injected intrathoracically into four species of mosquito. Virus infects haemocytes as early as 6 h post injection (p.i.) and infection was evident in these cells for as long as 4 days p.i. More than 90% of haemocytes were infected, most often the phagocytic granulocytes. Virus titres in the haemolymph increased from 24 h p.i. through 60 h p.i. Similar results were found when Aedes aegypti mosquitoes were injected with orally infectious Sindbis. These data prove that an arbovirus infects, and replicates in, haemocytes.

Original languageEnglish (US)
Pages (from-to)292-296
Number of pages5
JournalJournal of General Virology
Issue number2
StatePublished - 2009


Dive into the research topics of 'A Haemocyte tropism for an arbovirus'. Together they form a unique fingerprint.

Cite this