A gold standard set of mechanistically diverse enzyme superfamilies

Shoshana D. Brown, John A. Gerlt, Jennifer L. Seffernick, Patricia Babbitt

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Superfamily and family analyses provide an effective tool for the functional classification of proteins, but must be automated for use on large datasets. We describe a 'gold standard' set of enzyme superfamilies, clustered according to specific sequence, structure, and functional criteria, for use in the validation of family and superfamily clustering methods. The gold standard set represents four fold classes and differing clustering difficulties, and includes five superfamilies, 91 families, 4,887 sequences and 282 structures.

Original languageEnglish (US)
Article numberR8
JournalGenome biology
Issue number1
StatePublished - Jan 31 2006
Externally publishedYes


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