A glance at scope, tools, mechanisms, aims, and promise of chronobiology

F. Halberg, J. Halberg, Germaine G Cornelissen-Guillaume, S. Sanchez De La Pena, W. Jinyi, F. Halberg, E. Halberg

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Chronobiology is the science of life's structure in time. Rhythms with several frequencies characterize health and disease at different organizational levels. Chronobiometry provides methods for the quantitative and objective assessment of rhythms. New endpoints such as the amplitude (a measure of predictable extent of change) and the acrophase (a measure of timing of overall high values), are thus available. Even the mean value (MESOR) is defined more accurately when samples are collected at irregular intervals. It is also obtained with a reduced standard error as compared to the arithmetic mean. Sensitive parameter tests provide p values extended from a comparison of groups to the assessment of a therapeutic goal in the individual patient. Alteration in rhythm parameters may also be observed before a change in mean value can be detected. Such alterations may reflect protopathology and even chronorisk which may lay the basis for preventive action.

Original languageEnglish (US)
Pages (from-to)227-244
Number of pages18
JournalBrain Dysfunction
Issue number5-6
StatePublished - 1988


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