A germinal center-independent pathway generates unswitched memory B cells early in the primary response

Justin J. Taylor, Kathryn A Pape, Marc Jenkins

Research output: Contribution to journalArticlepeer-review

183 Scopus citations

Abstract

Memory B cells can be produced from the classical germinal center (GC) pathway or a less understood GC-independent route. We used antigen-based cell enrichment to assess the relative contributions of these pathways to the polyclonal memory B cell pool. We identified a CD38 + GL7 + B cell precursor population that differentiated directly into IgM + or isotype-switched (sw) Ig + memory B cells in a GC-independent fashion in response to strong CD40 stimulation. Alternatively, CD38 + GL7 + B cell precursors had the potential to become Bcl-6 + GC cells that then generated primarily swIg + memory B cells. These results demonstrate that early IgM + and swIg + memory B cells are products of a GC-independent pathway, whereas later switched Ig + memory B cells are products of GC cells.

Original languageEnglish (US)
Pages (from-to)597-606
Number of pages10
JournalJournal of Experimental Medicine
Volume209
Issue number3
DOIs
StatePublished - Mar 12 2012

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