A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content

Hui Zhang, Shou Zhi Wang, Zhi Peng Wang, Yang Da, Ning Wang, Xiao Xiang Hu, Yuan Dan Zhang, Yu Xiang Wang, Li Leng, Zhi Quan Tang, Hui Li

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Background: Genomic regions controlling abdominal fatness (AF) were studied in the Northeast Agricultural University broiler line divergently selected for AF. In this study, the chicken 60KSNP chip and extended haplotype homozygosity (EHH) test were used to detect genome-wide signatures of AF.Results: A total of 5357 and 5593 core regions were detected in the lean and fat lines, and 51 and 57 reached a significant level (P<0.01), respectively. A number of genes in the significant core regions, including RB1, BBS7, MAOA, MAOB, EHBP1, LRP2BP, LRP1B, MYO7A, MYO9A and PRPSAP1, were detected. These genes may be important for AF deposition in chickens.Conclusions: We provide a genome-wide map of selection signatures in the chicken genome, and make a contribution to the better understanding the mechanisms of selection for AF content in chickens. The selection for low AF in commercial breeding using this information will accelerate the breeding progress.

Original languageEnglish (US)
Article number704
JournalBMC Genomics
Volume13
Issue number1
DOIs
StatePublished - Dec 15 2012

Keywords

  • Abdominal fat
  • Extended haplotype homozygosity (EHH)
  • Selection signature

Fingerprint Dive into the research topics of 'A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content'. Together they form a unique fingerprint.

  • Cite this

    Zhang, H., Wang, S. Z., Wang, Z. P., Da, Y., Wang, N., Hu, X. X., Zhang, Y. D., Wang, Y. X., Leng, L., Tang, Z. Q., & Li, H. (2012). A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content. BMC Genomics, 13(1), [704]. https://doi.org/10.1186/1471-2164-13-704