A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes

Natalie R. Van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N. William Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R. Robertson, Paul M. McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Annalisa Perna, Erica Rurali, M. Loredana Marcovecchio, Robert P. Igo, Rany M. Salem, Norberto PericoMaria Lajer, Annemari Käräjämäki, Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu, Rob M. Van Dam, Guozhi Jiang, Claudia H.T. Tam, Andrea O.Y. Luk, Heung Man Lee, Cadmon K.P. Lim, Cheuk Chun Szeto, Wing Yee So, Juliana C.N. Chan, Su Fen Ang, Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy Jayne McKnight, Seamus Duffy, Warren, Marcus G. Pezzolesi, Michel Marre, Beata Gyorgy, Samy Hadjadj, Linda T. Hiraki, Tarunveer S. Ahluwalia, Peter Almgren, Christina Alexandra Schulz, Marju Orho-Melander, Allan Linneberg, Cramer Christensen, Daniel R. Witte, Niels Grarup, Ivan Brandslund, Olle Melander, Andrew D. Paterson, David Tregouet, Alexander P. Maxwell, Su Chi Lim, Ronald C.W. Ma, E. Shyong Tai, Shiro Maeda, Valeriya Lyssenko, Tiinamaija Tuomi, Andrzej S. Krolewski, Stephen S. Rich, Joel N. Hirschhorn, Jose C. Florez, David Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing, Giuseppe Remuzzi, Mary Julia Brosnan, Colin N.A. Palmer, Per Henrik Groop, Helen M. Colhoun, Leif C. Groop, Mark I. McCarthy, S. Koivula, T. Uggeldahl, T. Forslund, A. Halonen, A. Koistinen, P. Koskiaho, M. Laukkanen, J. Saltevo, M. Tiihonen, M. Forsen, H. Granlund, A. C. Jonsson, B. Nyroos, P. Kinnunen, A. Orvola, T. Salonen, A. Vähänen, K. R. Paldanius, M. Riihelä, L. Ryysy, K. H. Laukkanen, P. Nyländen, A. Sademies, S. Anderson, B. Asplund, U. Byskata, P. Liedes, M. Kuusela, T. Virkkala, A. Nikkola, E. Ritola, T. M. Niska, H. Saarinen, S. E. Oukko-Ruponen, T. Virtanen, V. A. Lyytinen, P. H. Kari, T. Simonen, S. A. Kaprio, J. Kärkkäinen, B. Rantaeskola, T. P. Kääriäinen, J. Haaga, A. L. Pietiläinen, S. Klemetti, T. Nyandoto, E. Rontu, S. Satuli-Autere, K. R. Toivonen, H. V. Lansimaki, R. Ahonen, M. Ivaska-Suomela, A. Jauhiainen, M. M. Laine, T. Pellonpää, R. Puranen, M. A. Airas, J. Laakso, K. Rautavaara, R. M. Erola, E. Jatkola, T. R. Lönnblad, A. Malm, J. Mäkelä, E. Rautamo, P. Hentunen, J. Lagerstam, M. Feodoroff, D. Gordin, O. Heikkilä, K. Hietala, J. Fagerudd, M. Korolainen, L. Kyllönen, J. Kytö, S. Lindh, K. Pettersson-Fernholm, M. Rosengård-Bärlund, A. Sandelin, L. Thorn, J. Tuomikangas, T. Vesisenaho, J. Wadén, V. Sipilä, F. T. Kalliomäki, J. Koskelainen, R. Nikkanen, N. Savolainen, H. Sulonen, E. Valtonen, L. Norvio, A. Hämäläinen, E. Toivanen, J. A. Parta, I. Pirttiniemi, S. Aranko, S. Ervasti, R. Kauppinen-Mäkelin, A. Kuusisto, T. Leppälä, K. Nikkilä, L. Pekkonen, K. S. Jokelainen, K. Kananen, M. Karjalainen, P. Kemppainen, A. M. Mankinen, A. Reponen, M. Sankari, P. Suominen, A. Lappalainen, M. Liimatainen, J. Santaholma, A. Aimolahti, E. Huovinen, V. Ilkka, M. Lehtimäki, E. Pälikkö-Kontinen, A. Vanhanen, E. Koskinen, T. Siitonen, E. Huttunen, R. Ikäheimo, P. Karhapää, P. Kekäläinen, M. Laakso, T. Lakka, E. Lampainen, L. Moilanen, S. Tanskanen, L. Niskanen, U. Tuovinen, I. Vauhkonen, E. Voutilainen, Y. Huang, H. Y. Lan, S. Lok, B. Tomlinson, S. K.W. Tsui, W. Yu, K. Y.L. Yip, T. F. Chan, X. Fan, N. Tang, X. Tian, K. K.H. Chan, F. Xie, A. C.W. Ng, G. P.Y. Cheung, M. W. Yeung, S. Mai, F. Xie, S. Zhang, P. Yu, M. Weng, D. A. Savage, J. Walker, S. Thomas, G. C. Viberti, A. J.M. Boulton, S. Marshall, A. G. Demaine, B. A. Millward, S. C. Bain, V. P. Mäkinen, A. J. Ahola, E. Dahlström, D. Gordin, O. Heikkilä, K. Hietala, J. Kytö, M. Lehto, R. Lithovius, N. M. Panduru, M. Parkkonen, M. Rosengård-Bärlund, M. Saraheimo, J. Söderlund, A. Soro-Paavonen, A. Syreeni, L. M. Thorn, N. Tolonen, J. Wadén, G. J. McKay, T. Isakova, C. Guiducci, A. Taylor, D. B. Mirel, W. W. Williams, E. P. Brennan, D. M. Sadlier, F. Martin, C. Godson, L. Mayer, R. Gubitosi-Klug, P. Bourne, M. Schutta, M. E. Lackaye, N. S. Gregory, D. Kruger, J. K. Jones, A. Bhan, E. Golden, L. Aiello, M. Larkin, D. Nathan, G. Ziegler, S. Caulder, C. Pittman, L. Luttrell, M. Lopes-Virella, M. Johnson, K. Gunyou, R. Bergenstal, B. Vittetoe, W. Sivitz, N. Flaherty, J. Bantle, S. Hitt, D. Goldstein, D. Hainsworth, L. Cimino, T. Orchard, C. Wigley, S. Dagogo-Jack, S. Strowig, P. Raskin, A. Barnie, B. Zinman, R. Fahlstrom, J. Palmer, J. Harth, M. Driscoll, C. McDonald, J. Lipps Hagan, M. May, L. Levandoski, N. White, P. Gatcomb, W. Tamborlane, D. Adelman, S. Colson, M. Molitch, G. Lorenzi, S. Mudaliar, S. Johnsonbaugh, R. Miller, J. Canady, D. Schade, M. L. Bernal, J. Malone, A. Morrison, C. Martin, W. Herman, R. Pop-Busui, C. Cowie, E. Leschek, P. Cleary, J. Lachin, B. Zinman, G. Lorenzi, B. Braffett, Michael W Steffes, V. Arends, B. Blodi, R. Danis, D. Lawrence, H. Wabers, E. Soliman, Z. M. Zhang, C. Campbell, S. Hensley, L. Keasler, M. Mark, M. Albertini, C. Boustany, A. Ehlgen, M. Gerl, J. Huber, C. Schölch, H. Zimdahl-Gelling, E. Agardh, T. Ajanki, N. Al Maghrabi, J. Apelqvist, E. Bengtsson, L. Berglund, H. Björckbacka, U. Blom-Nilsson, M. Borell, A. Burström, C. Cilio, M. Cinthio, K. Dreja, P. Dunér, D. Engelbertsen, J. Fadista, M. Gomez, I. Goncalves, B. Hedblad, A. Hultgårdh, M. E. Johansson, C. Kennbäck, J. Kravic, A. Lernmark, E. Lindholm, C. Ling, H. Luthman, M. Neptin, J. Nilsson, P. Nilsson, T. Nilsson, G. Nordin, E. Ottoson-Laakso, A. Persson, M. Persson, M. A. Persson, J. Postma, E. Pranter, S. Rattik, G. Sterner, L. Tindberg, M. Wigren, A. Zetterqvist, M. Åkerlund, G. Ostling, T. Kanninen, A. Ahonen-Bishopp, A. Eliasson, T. Herrala, P. Tikka-Kleemola, A. Hamsten, C. Betsholtz, A. Björkholm, F. Foroogh, G. Genové, K. Gertow, B. Gigante, B. He, K. Leander, O. McLeod, M. Nastase-Mannila, J. Patrakka, A. Silveira, R. Strawbridge, K. Tryggvason, M. Vikström, J. Ohrvik, A. M. Österholm, B. Thorand, C. Gieger, H. Grallert, T. Ludwig, B. Nitz, A. Schneider, R. Wang-Sattler, A. Zierer, A. Benigni, R. Donadelli, M. D. Lesti, M. Noris, R. Piras, P. Ruggenenti, L. Chassin, N. Dalton, J. Deanfield, J. Horsford, C. Rice, J. Rudd, N. Walker, K. Whitehead, M. Wong, F. Adams, T. Akbar, J. Belch, F. Dove, A. Ellingford, B. Farran, M. Ferguson, G. Henderson, G. Houston, F. Khan, G. Leese, S. Livingstone, H. Looker, M. McCann, S. McGurnaghan, A. Morris, D. Newton, E. Pearson, G. Reekie, N. Smith, A. Shore, K. Aizawa, C. Ball, N. Bellenger, F. Casanova, T. Frayling, P. Gates, K. Gooding, A. Hattersley, R. Ling, D. Mawson, R. Shandas, D. Strain, C. Thorn, U. Smith, A. Hammarstedt, H. Häring, G. Sesti, E. Fagerholm, M. Parkkonen, N. Tolonen, I. Toppila, V. Salomaa, A. Havulinna, K. Kristiansson, P. Okamo, T. Peltola, M. Perola, A. Pietilä, S. Ripatti, M. Taimi, S. Ylä-Herttuala, M. Babu, M. Dijkstra, E. Gurzeler, J. Huusko, I. Kholová, M. Laakso, M. Merentie, M. Poikolainen, C. Groves, T. Juliusdottir, F. Karpe, V. Lagou, A. Morris, C. Cobelli, B. Di Camillo, Francesca Finotello, F. Sambo, G. Toffolo, E. Trifoglio, R. Bellazzi, N. Barbarini, M. Bucalo, C. Larizza, P. Magni, A. Malovini, S. Marini, F. Mulas, S. Quaglini, L. Sacchi, F. Vitali, E. Ferrannini, B. Boldrini, M. Kozakova, A. Mari, C. Morizzo, L. Mota, A. Natali, C. Palombo, E. Venturi, M. Walker, C. Patrono, F. Pagliaccia, B. Rocca, P. Nuutila, J. Haukkala, J. Knuuti, A. Roivainen, A. Saraste, P. McKeague, M. Colombo, B. Steckel-Hamann, K. Bokvist, S. Shankar, M. Thomas, L. M. Gan, S. Heinonen, A. C. Jönsson-Rylander, R. Momo, V. Schnecke, R. Unwin, A. Walentinsson, C. Whatling, E. Nogoceke, G. D. Pacheco, I. Formentini, T. Schindler, P. Tortoli, L. Bassi, E. Boni, A. Dallai, F. Guidi, M. Lenge, R. Matera, A. Ramalli, S. Ricci, J. Viti, B. Jablonka, D. Crowther, J. Gassenhuber, S. Hess, T. Hubschle, H. P. Juretschke, H. Rutten, T. Sadowski, P. Wohlfart, V. Clerin, C. Hyde, A. Malarstig, N. Pullen, M. Tilley, T. Tuthill, C. Vangjeli

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 3 10 28 ) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.

Original languageEnglish (US)
Pages (from-to)1414-1427
Number of pages14
JournalDiabetes
Volume67
Issue number7
DOIs
StatePublished - Jul 1 2018

Fingerprint

Genome-Wide Association Study
Diabetic Nephropathies
Type 2 Diabetes Mellitus
Phenotype
Glomerular Filtration Rate
Sample Size

Cite this

Van Zuydam, N. R., Ahlqvist, E., Sandholm, N., Deshmukh, H., William Rayner, N., Abdalla, M., ... Vangjeli, C. (2018). A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes. Diabetes, 67(7), 1414-1427. https://doi.org/10.2337/db17-0914

A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes. / Van Zuydam, Natalie R.; Ahlqvist, Emma; Sandholm, Niina; Deshmukh, Harshal; William Rayner, N.; Abdalla, Moustafa; Ladenvall, Claes; Ziemek, Daniel; Fauman, Eric; Robertson, Neil R.; McKeigue, Paul M.; Valo, Erkka; Forsblom, Carol; Harjutsalo, Valma; Perna, Annalisa; Rurali, Erica; Loredana Marcovecchio, M.; Igo, Robert P.; Salem, Rany M.; Perico, Norberto; Lajer, Maria; Käräjämäki, Annemari; Imamura, Minako; Kubo, Michiaki; Takahashi, Atsushi; Sim, Xueling; Liu, Jianjun; Van Dam, Rob M.; Jiang, Guozhi; Tam, Claudia H.T.; Luk, Andrea O.Y.; Lee, Heung Man; Lim, Cadmon K.P.; Szeto, Cheuk Chun; So, Wing Yee; Chan, Juliana C.N.; Ang, Su Fen; Dorajoo, Rajkumar; Wang, Ling; Clara, Tan Si Hua; McKnight, Amy Jayne; Duffy, Seamus; Warren; Pezzolesi, Marcus G.; Marre, Michel; Gyorgy, Beata; Hadjadj, Samy; Hiraki, Linda T.; Ahluwalia, Tarunveer S.; Almgren, Peter; Schulz, Christina Alexandra; Orho-Melander, Marju; Linneberg, Allan; Christensen, Cramer; Witte, Daniel R.; Grarup, Niels; Brandslund, Ivan; Melander, Olle; Paterson, Andrew D.; Tregouet, David; Maxwell, Alexander P.; Lim, Su Chi; Ma, Ronald C.W.; Shyong Tai, E.; Maeda, Shiro; Lyssenko, Valeriya; Tuomi, Tiinamaija; Krolewski, Andrzej S.; Rich, Stephen S.; Hirschhorn, Joel N.; Florez, Jose C.; Dunger, David; Pedersen, Oluf; Hansen, Torben; Rossing, Peter; Remuzzi, Giuseppe; Brosnan, Mary Julia; Palmer, Colin N.A.; Groop, Per Henrik; Colhoun, Helen M.; Groop, Leif C.; McCarthy, Mark I.; Koivula, S.; Uggeldahl, T.; Forslund, T.; Halonen, A.; Koistinen, A.; Koskiaho, P.; Laukkanen, M.; Saltevo, J.; Tiihonen, M.; Forsen, M.; Granlund, H.; Jonsson, A. C.; Nyroos, B.; Kinnunen, P.; Orvola, A.; Salonen, T.; Vähänen, A.; Paldanius, K. R.; Riihelä, M.; Ryysy, L.; Laukkanen, K. H.; Nyländen, P.; Sademies, A.; Anderson, S.; Asplund, B.; Byskata, U.; Liedes, P.; Kuusela, M.; Virkkala, T.; Nikkola, A.; Ritola, E.; Niska, T. M.; Saarinen, H.; Oukko-Ruponen, S. E.; Virtanen, T.; Lyytinen, V. A.; Kari, P. H.; Simonen, T.; Kaprio, S. A.; Kärkkäinen, J.; Rantaeskola, B.; Kääriäinen, T. P.; Haaga, J.; Pietiläinen, A. L.; Klemetti, S.; Nyandoto, T.; Rontu, E.; Satuli-Autere, S.; Toivonen, K. R.; Lansimaki, H. V.; Ahonen, R.; Ivaska-Suomela, M.; Jauhiainen, A.; Laine, M. M.; Pellonpää, T.; Puranen, R.; Airas, M. A.; Laakso, J.; Rautavaara, K.; Erola, R. M.; Jatkola, E.; Lönnblad, T. R.; Malm, A.; Mäkelä, J.; Rautamo, E.; Hentunen, P.; Lagerstam, J.; Feodoroff, M.; Gordin, D.; Heikkilä, O.; Hietala, K.; Fagerudd, J.; Korolainen, M.; Kyllönen, L.; Kytö, J.; Lindh, S.; Pettersson-Fernholm, K.; Rosengård-Bärlund, M.; Sandelin, A.; Thorn, L.; Tuomikangas, J.; Vesisenaho, T.; Wadén, J.; Sipilä, V.; Kalliomäki, F. T.; Koskelainen, J.; Nikkanen, R.; Savolainen, N.; Sulonen, H.; Valtonen, E.; Norvio, L.; Hämäläinen, A.; Toivanen, E.; Parta, J. A.; Pirttiniemi, I.; Aranko, S.; Ervasti, S.; Kauppinen-Mäkelin, R.; Kuusisto, A.; Leppälä, T.; Nikkilä, K.; Pekkonen, L.; Jokelainen, K. S.; Kananen, K.; Karjalainen, M.; Kemppainen, P.; Mankinen, A. M.; Reponen, A.; Sankari, M.; Suominen, P.; Lappalainen, A.; Liimatainen, M.; Santaholma, J.; Aimolahti, A.; Huovinen, E.; Ilkka, V.; Lehtimäki, M.; Pälikkö-Kontinen, E.; Vanhanen, A.; Koskinen, E.; Siitonen, T.; Huttunen, E.; Ikäheimo, R.; Karhapää, P.; Kekäläinen, P.; Laakso, M.; Lakka, T.; Lampainen, E.; Moilanen, L.; Tanskanen, S.; Niskanen, L.; Tuovinen, U.; Vauhkonen, I.; Voutilainen, E.; Huang, Y.; Lan, H. Y.; Lok, S.; Tomlinson, B.; Tsui, S. K.W.; Yu, W.; Yip, K. Y.L.; Chan, T. F.; Fan, X.; Tang, N.; Tian, X.; Chan, K. K.H.; Xie, F.; Ng, A. C.W.; Cheung, G. P.Y.; Yeung, M. W.; Mai, S.; Xie, F.; Zhang, S.; Yu, P.; Weng, M.; Savage, D. A.; Walker, J.; Thomas, S.; Viberti, G. C.; Boulton, A. J.M.; Marshall, S.; Demaine, A. G.; Millward, B. A.; Bain, S. C.; Mäkinen, V. P.; Ahola, A. J.; Dahlström, E.; Gordin, D.; Heikkilä, O.; Hietala, K.; Kytö, J.; Lehto, M.; Lithovius, R.; Panduru, N. M.; Parkkonen, M.; Rosengård-Bärlund, M.; Saraheimo, M.; Söderlund, J.; Soro-Paavonen, A.; Syreeni, A.; Thorn, L. M.; Tolonen, N.; Wadén, J.; McKay, G. J.; Isakova, T.; Guiducci, C.; Taylor, A.; Mirel, D. B.; Williams, W. W.; Brennan, E. P.; Sadlier, D. M.; Martin, F.; Godson, C.; Mayer, L.; Gubitosi-Klug, R.; Bourne, P.; Schutta, M.; Lackaye, M. E.; Gregory, N. S.; Kruger, D.; Jones, J. K.; Bhan, A.; Golden, E.; Aiello, L.; Larkin, M.; Nathan, D.; Ziegler, G.; Caulder, S.; Pittman, C.; Luttrell, L.; Lopes-Virella, M.; Johnson, M.; Gunyou, K.; Bergenstal, R.; Vittetoe, B.; Sivitz, W.; Flaherty, N.; Bantle, J.; Hitt, S.; Goldstein, D.; Hainsworth, D.; Cimino, L.; Orchard, T.; Wigley, C.; Dagogo-Jack, S.; Strowig, S.; Raskin, P.; Barnie, A.; Zinman, B.; Fahlstrom, R.; Palmer, J.; Harth, J.; Driscoll, M.; McDonald, C.; Lipps Hagan, J.; May, M.; Levandoski, L.; White, N.; Gatcomb, P.; Tamborlane, W.; Adelman, D.; Colson, S.; Molitch, M.; Lorenzi, G.; Mudaliar, S.; Johnsonbaugh, S.; Miller, R.; Canady, J.; Schade, D.; Bernal, M. L.; Malone, J.; Morrison, A.; Martin, C.; Herman, W.; Pop-Busui, R.; Cowie, C.; Leschek, E.; Cleary, P.; Lachin, J.; Zinman, B.; Lorenzi, G.; Braffett, B.; Steffes, Michael W; Arends, V.; Blodi, B.; Danis, R.; Lawrence, D.; Wabers, H.; Soliman, E.; Zhang, Z. M.; Campbell, C.; Hensley, S.; Keasler, L.; Mark, M.; Albertini, M.; Boustany, C.; Ehlgen, A.; Gerl, M.; Huber, J.; Schölch, C.; Zimdahl-Gelling, H.; Agardh, E.; Ajanki, T.; Al Maghrabi, N.; Apelqvist, J.; Bengtsson, E.; Berglund, L.; Björckbacka, H.; Blom-Nilsson, U.; Borell, M.; Burström, A.; Cilio, C.; Cinthio, M.; Dreja, K.; Dunér, P.; Engelbertsen, D.; Fadista, J.; Gomez, M.; Goncalves, I.; Hedblad, B.; Hultgårdh, A.; Johansson, M. E.; Kennbäck, C.; Kravic, J.; Lernmark, A.; Lindholm, E.; Ling, C.; Luthman, H.; Neptin, M.; Nilsson, J.; Nilsson, P.; Nilsson, T.; Nordin, G.; Ottoson-Laakso, E.; Persson, A.; Persson, M.; Persson, M. A.; Postma, J.; Pranter, E.; Rattik, S.; Sterner, G.; Tindberg, L.; Wigren, M.; Zetterqvist, A.; Åkerlund, M.; Ostling, G.; Kanninen, T.; Ahonen-Bishopp, A.; Eliasson, A.; Herrala, T.; Tikka-Kleemola, P.; Hamsten, A.; Betsholtz, C.; Björkholm, A.; Foroogh, F.; Genové, G.; Gertow, K.; Gigante, B.; He, B.; Leander, K.; McLeod, O.; Nastase-Mannila, M.; Patrakka, J.; Silveira, A.; Strawbridge, R.; Tryggvason, K.; Vikström, M.; Ohrvik, J.; Österholm, A. M.; Thorand, B.; Gieger, C.; Grallert, H.; Ludwig, T.; Nitz, B.; Schneider, A.; Wang-Sattler, R.; Zierer, A.; Benigni, A.; Donadelli, R.; Lesti, M. D.; Noris, M.; Piras, R.; Ruggenenti, P.; Chassin, L.; Dalton, N.; Deanfield, J.; Horsford, J.; Rice, C.; Rudd, J.; Walker, N.; Whitehead, K.; Wong, M.; Adams, F.; Akbar, T.; Belch, J.; Dove, F.; Ellingford, A.; Farran, B.; Ferguson, M.; Henderson, G.; Houston, G.; Khan, F.; Leese, G.; Livingstone, S.; Looker, H.; McCann, M.; McGurnaghan, S.; Morris, A.; Newton, D.; Pearson, E.; Reekie, G.; Smith, N.; Shore, A.; Aizawa, K.; Ball, C.; Bellenger, N.; Casanova, F.; Frayling, T.; Gates, P.; Gooding, K.; Hattersley, A.; Ling, R.; Mawson, D.; Shandas, R.; Strain, D.; Thorn, C.; Smith, U.; Hammarstedt, A.; Häring, H.; Sesti, G.; Fagerholm, E.; Parkkonen, M.; Tolonen, N.; Toppila, I.; Salomaa, V.; Havulinna, A.; Kristiansson, K.; Okamo, P.; Peltola, T.; Perola, M.; Pietilä, A.; Ripatti, S.; Taimi, M.; Ylä-Herttuala, S.; Babu, M.; Dijkstra, M.; Gurzeler, E.; Huusko, J.; Kholová, I.; Laakso, M.; Merentie, M.; Poikolainen, M.; Groves, C.; Juliusdottir, T.; Karpe, F.; Lagou, V.; Morris, A.; Cobelli, C.; Di Camillo, B.; Finotello, Francesca; Sambo, F.; Toffolo, G.; Trifoglio, E.; Bellazzi, R.; Barbarini, N.; Bucalo, M.; Larizza, C.; Magni, P.; Malovini, A.; Marini, S.; Mulas, F.; Quaglini, S.; Sacchi, L.; Vitali, F.; Ferrannini, E.; Boldrini, B.; Kozakova, M.; Mari, A.; Morizzo, C.; Mota, L.; Natali, A.; Palombo, C.; Venturi, E.; Walker, M.; Patrono, C.; Pagliaccia, F.; Rocca, B.; Nuutila, P.; Haukkala, J.; Knuuti, J.; Roivainen, A.; Saraste, A.; McKeague, P.; Colombo, M.; Steckel-Hamann, B.; Bokvist, K.; Shankar, S.; Thomas, M.; Gan, L. M.; Heinonen, S.; Jönsson-Rylander, A. C.; Momo, R.; Schnecke, V.; Unwin, R.; Walentinsson, A.; Whatling, C.; Nogoceke, E.; Pacheco, G. D.; Formentini, I.; Schindler, T.; Tortoli, P.; Bassi, L.; Boni, E.; Dallai, A.; Guidi, F.; Lenge, M.; Matera, R.; Ramalli, A.; Ricci, S.; Viti, J.; Jablonka, B.; Crowther, D.; Gassenhuber, J.; Hess, S.; Hubschle, T.; Juretschke, H. P.; Rutten, H.; Sadowski, T.; Wohlfart, P.; Clerin, V.; Hyde, C.; Malarstig, A.; Pullen, N.; Tilley, M.; Tuthill, T.; Vangjeli, C.

In: Diabetes, Vol. 67, No. 7, 01.07.2018, p. 1414-1427.

Research output: Contribution to journalArticle

Van Zuydam, NR, Ahlqvist, E, Sandholm, N, Deshmukh, H, William Rayner, N, Abdalla, M, Ladenvall, C, Ziemek, D, Fauman, E, Robertson, NR, McKeigue, PM, Valo, E, Forsblom, C, Harjutsalo, V, Perna, A, Rurali, E, Loredana Marcovecchio, M, Igo, RP, Salem, RM, Perico, N, Lajer, M, Käräjämäki, A, Imamura, M, Kubo, M, Takahashi, A, Sim, X, Liu, J, Van Dam, RM, Jiang, G, Tam, CHT, Luk, AOY, Lee, HM, Lim, CKP, Szeto, CC, So, WY, Chan, JCN, Ang, SF, Dorajoo, R, Wang, L, Clara, TSH, McKnight, AJ, Duffy, S, Warren, Pezzolesi, MG, Marre, M, Gyorgy, B, Hadjadj, S, Hiraki, LT, Ahluwalia, TS, Almgren, P, Schulz, CA, Orho-Melander, M, Linneberg, A, Christensen, C, Witte, DR, Grarup, N, Brandslund, I, Melander, O, Paterson, AD, Tregouet, D, Maxwell, AP, Lim, SC, Ma, RCW, Shyong Tai, E, Maeda, S, Lyssenko, V, Tuomi, T, Krolewski, AS, Rich, SS, Hirschhorn, JN, Florez, JC, Dunger, D, Pedersen, O, Hansen, T, Rossing, P, Remuzzi, G, Brosnan, MJ, Palmer, CNA, Groop, PH, Colhoun, HM, Groop, LC, McCarthy, MI, Koivula, S, Uggeldahl, T, Forslund, T, Halonen, A, Koistinen, A, Koskiaho, P, Laukkanen, M, Saltevo, J, Tiihonen, M, Forsen, M, Granlund, H, Jonsson, AC, Nyroos, B, Kinnunen, P, Orvola, A, Salonen, T, Vähänen, A, Paldanius, KR, Riihelä, M, Ryysy, L, Laukkanen, KH, Nyländen, P, Sademies, A, Anderson, S, Asplund, B, Byskata, U, Liedes, P, Kuusela, M, Virkkala, T, Nikkola, A, Ritola, E, Niska, TM, Saarinen, H, Oukko-Ruponen, SE, Virtanen, T, Lyytinen, VA, Kari, PH, Simonen, T, Kaprio, SA, Kärkkäinen, J, Rantaeskola, B, Kääriäinen, TP, Haaga, J, Pietiläinen, AL, Klemetti, S, Nyandoto, T, Rontu, E, Satuli-Autere, S, Toivonen, KR, Lansimaki, HV, Ahonen, R, Ivaska-Suomela, M, Jauhiainen, A, Laine, MM, Pellonpää, T, Puranen, R, Airas, MA, Laakso, J, Rautavaara, K, Erola, RM, Jatkola, E, Lönnblad, TR, Malm, A, Mäkelä, J, Rautamo, E, Hentunen, P, Lagerstam, J, Feodoroff, M, Gordin, D, Heikkilä, O, Hietala, K, Fagerudd, J, Korolainen, M, Kyllönen, L, Kytö, J, Lindh, S, Pettersson-Fernholm, K, Rosengård-Bärlund, M, Sandelin, A, Thorn, L, Tuomikangas, J, Vesisenaho, T, Wadén, J, Sipilä, V, Kalliomäki, FT, Koskelainen, J, Nikkanen, R, Savolainen, N, Sulonen, H, Valtonen, E, Norvio, L, Hämäläinen, A, Toivanen, E, Parta, JA, Pirttiniemi, I, Aranko, S, Ervasti, S, Kauppinen-Mäkelin, R, Kuusisto, A, Leppälä, T, Nikkilä, K, Pekkonen, L, Jokelainen, KS, Kananen, K, Karjalainen, M, Kemppainen, P, Mankinen, AM, Reponen, A, Sankari, M, Suominen, P, Lappalainen, A, Liimatainen, M, Santaholma, J, Aimolahti, A, Huovinen, E, Ilkka, V, Lehtimäki, M, Pälikkö-Kontinen, E, Vanhanen, A, Koskinen, E, Siitonen, T, Huttunen, E, Ikäheimo, R, Karhapää, P, Kekäläinen, P, Laakso, M, Lakka, T, Lampainen, E, Moilanen, L, Tanskanen, S, Niskanen, L, Tuovinen, U, Vauhkonen, I, Voutilainen, E, Huang, Y, Lan, HY, Lok, S, Tomlinson, B, Tsui, SKW, Yu, W, Yip, KYL, Chan, TF, Fan, X, Tang, N, Tian, X, Chan, KKH, Xie, F, Ng, ACW, Cheung, GPY, Yeung, MW, Mai, S, Xie, F, Zhang, S, Yu, P, Weng, M, Savage, DA, Walker, J, Thomas, S, Viberti, GC, Boulton, AJM, Marshall, S, Demaine, AG, Millward, BA, Bain, SC, Mäkinen, VP, Ahola, AJ, Dahlström, E, Gordin, D, Heikkilä, O, Hietala, K, Kytö, J, Lehto, M, Lithovius, R, Panduru, NM, Parkkonen, M, Rosengård-Bärlund, M, Saraheimo, M, Söderlund, J, Soro-Paavonen, A, Syreeni, A, Thorn, LM, Tolonen, N, Wadén, J, McKay, GJ, Isakova, T, Guiducci, C, Taylor, A, Mirel, DB, Williams, WW, Brennan, EP, Sadlier, DM, Martin, F, Godson, C, Mayer, L, Gubitosi-Klug, R, Bourne, P, Schutta, M, Lackaye, ME, Gregory, NS, Kruger, D, Jones, JK, Bhan, A, Golden, E, Aiello, L, Larkin, M, Nathan, D, Ziegler, G, Caulder, S, Pittman, C, Luttrell, L, Lopes-Virella, M, Johnson, M, Gunyou, K, Bergenstal, R, Vittetoe, B, Sivitz, W, Flaherty, N, Bantle, J, Hitt, S, Goldstein, D, Hainsworth, D, Cimino, L, Orchard, T, Wigley, C, Dagogo-Jack, S, Strowig, S, Raskin, P, Barnie, A, Zinman, B, Fahlstrom, R, Palmer, J, Harth, J, Driscoll, M, McDonald, C, Lipps Hagan, J, May, M, Levandoski, L, White, N, Gatcomb, P, Tamborlane, W, Adelman, D, Colson, S, Molitch, M, Lorenzi, G, Mudaliar, S, Johnsonbaugh, S, Miller, R, Canady, J, Schade, D, Bernal, ML, Malone, J, Morrison, A, Martin, C, Herman, W, Pop-Busui, R, Cowie, C, Leschek, E, Cleary, P, Lachin, J, Zinman, B, Lorenzi, G, Braffett, B, Steffes, MW, Arends, V, Blodi, B, Danis, R, Lawrence, D, Wabers, H, Soliman, E, Zhang, ZM, Campbell, C, Hensley, S, Keasler, L, Mark, M, Albertini, M, Boustany, C, Ehlgen, A, Gerl, M, Huber, J, Schölch, C, Zimdahl-Gelling, H, Agardh, E, Ajanki, T, Al Maghrabi, N, Apelqvist, J, Bengtsson, E, Berglund, L, Björckbacka, H, Blom-Nilsson, U, Borell, M, Burström, A, Cilio, C, Cinthio, M, Dreja, K, Dunér, P, Engelbertsen, D, Fadista, J, Gomez, M, Goncalves, I, Hedblad, B, Hultgårdh, A, Johansson, ME, Kennbäck, C, Kravic, J, Lernmark, A, Lindholm, E, Ling, C, Luthman, H, Neptin, M, Nilsson, J, Nilsson, P, Nilsson, T, Nordin, G, Ottoson-Laakso, E, Persson, A, Persson, M, Persson, MA, Postma, J, Pranter, E, Rattik, S, Sterner, G, Tindberg, L, Wigren, M, Zetterqvist, A, Åkerlund, M, Ostling, G, Kanninen, T, Ahonen-Bishopp, A, Eliasson, A, Herrala, T, Tikka-Kleemola, P, Hamsten, A, Betsholtz, C, Björkholm, A, Foroogh, F, Genové, G, Gertow, K, Gigante, B, He, B, Leander, K, McLeod, O, Nastase-Mannila, M, Patrakka, J, Silveira, A, Strawbridge, R, Tryggvason, K, Vikström, M, Ohrvik, J, Österholm, AM, Thorand, B, Gieger, C, Grallert, H, Ludwig, T, Nitz, B, Schneider, A, Wang-Sattler, R, Zierer, A, Benigni, A, Donadelli, R, Lesti, MD, Noris, M, Piras, R, Ruggenenti, P, Chassin, L, Dalton, N, Deanfield, J, Horsford, J, Rice, C, Rudd, J, Walker, N, Whitehead, K, Wong, M, Adams, F, Akbar, T, Belch, J, Dove, F, Ellingford, A, Farran, B, Ferguson, M, Henderson, G, Houston, G, Khan, F, Leese, G, Livingstone, S, Looker, H, McCann, M, McGurnaghan, S, Morris, A, Newton, D, Pearson, E, Reekie, G, Smith, N, Shore, A, Aizawa, K, Ball, C, Bellenger, N, Casanova, F, Frayling, T, Gates, P, Gooding, K, Hattersley, A, Ling, R, Mawson, D, Shandas, R, Strain, D, Thorn, C, Smith, U, Hammarstedt, A, Häring, H, Sesti, G, Fagerholm, E, Parkkonen, M, Tolonen, N, Toppila, I, Salomaa, V, Havulinna, A, Kristiansson, K, Okamo, P, Peltola, T, Perola, M, Pietilä, A, Ripatti, S, Taimi, M, Ylä-Herttuala, S, Babu, M, Dijkstra, M, Gurzeler, E, Huusko, J, Kholová, I, Laakso, M, Merentie, M, Poikolainen, M, Groves, C, Juliusdottir, T, Karpe, F, Lagou, V, Morris, A, Cobelli, C, Di Camillo, B, Finotello, F, Sambo, F, Toffolo, G, Trifoglio, E, Bellazzi, R, Barbarini, N, Bucalo, M, Larizza, C, Magni, P, Malovini, A, Marini, S, Mulas, F, Quaglini, S, Sacchi, L, Vitali, F, Ferrannini, E, Boldrini, B, Kozakova, M, Mari, A, Morizzo, C, Mota, L, Natali, A, Palombo, C, Venturi, E, Walker, M, Patrono, C, Pagliaccia, F, Rocca, B, Nuutila, P, Haukkala, J, Knuuti, J, Roivainen, A, Saraste, A, McKeague, P, Colombo, M, Steckel-Hamann, B, Bokvist, K, Shankar, S, Thomas, M, Gan, LM, Heinonen, S, Jönsson-Rylander, AC, Momo, R, Schnecke, V, Unwin, R, Walentinsson, A, Whatling, C, Nogoceke, E, Pacheco, GD, Formentini, I, Schindler, T, Tortoli, P, Bassi, L, Boni, E, Dallai, A, Guidi, F, Lenge, M, Matera, R, Ramalli, A, Ricci, S, Viti, J, Jablonka, B, Crowther, D, Gassenhuber, J, Hess, S, Hubschle, T, Juretschke, HP, Rutten, H, Sadowski, T, Wohlfart, P, Clerin, V, Hyde, C, Malarstig, A, Pullen, N, Tilley, M, Tuthill, T & Vangjeli, C 2018, 'A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes', Diabetes, vol. 67, no. 7, pp. 1414-1427. https://doi.org/10.2337/db17-0914
Van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, William Rayner N, Abdalla M et al. A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes. Diabetes. 2018 Jul 1;67(7):1414-1427. https://doi.org/10.2337/db17-0914
Van Zuydam, Natalie R. ; Ahlqvist, Emma ; Sandholm, Niina ; Deshmukh, Harshal ; William Rayner, N. ; Abdalla, Moustafa ; Ladenvall, Claes ; Ziemek, Daniel ; Fauman, Eric ; Robertson, Neil R. ; McKeigue, Paul M. ; Valo, Erkka ; Forsblom, Carol ; Harjutsalo, Valma ; Perna, Annalisa ; Rurali, Erica ; Loredana Marcovecchio, M. ; Igo, Robert P. ; Salem, Rany M. ; Perico, Norberto ; Lajer, Maria ; Käräjämäki, Annemari ; Imamura, Minako ; Kubo, Michiaki ; Takahashi, Atsushi ; Sim, Xueling ; Liu, Jianjun ; Van Dam, Rob M. ; Jiang, Guozhi ; Tam, Claudia H.T. ; Luk, Andrea O.Y. ; Lee, Heung Man ; Lim, Cadmon K.P. ; Szeto, Cheuk Chun ; So, Wing Yee ; Chan, Juliana C.N. ; Ang, Su Fen ; Dorajoo, Rajkumar ; Wang, Ling ; Clara, Tan Si Hua ; McKnight, Amy Jayne ; Duffy, Seamus ; Warren ; Pezzolesi, Marcus G. ; Marre, Michel ; Gyorgy, Beata ; Hadjadj, Samy ; Hiraki, Linda T. ; Ahluwalia, Tarunveer S. ; Almgren, Peter ; Schulz, Christina Alexandra ; Orho-Melander, Marju ; Linneberg, Allan ; Christensen, Cramer ; Witte, Daniel R. ; Grarup, Niels ; Brandslund, Ivan ; Melander, Olle ; Paterson, Andrew D. ; Tregouet, David ; Maxwell, Alexander P. ; Lim, Su Chi ; Ma, Ronald C.W. ; Shyong Tai, E. ; Maeda, Shiro ; Lyssenko, Valeriya ; Tuomi, Tiinamaija ; Krolewski, Andrzej S. ; Rich, Stephen S. ; Hirschhorn, Joel N. ; Florez, Jose C. ; Dunger, David ; Pedersen, Oluf ; Hansen, Torben ; Rossing, Peter ; Remuzzi, Giuseppe ; Brosnan, Mary Julia ; Palmer, Colin N.A. ; Groop, Per Henrik ; Colhoun, Helen M. ; Groop, Leif C. ; McCarthy, Mark I. ; Koivula, S. ; Uggeldahl, T. ; Forslund, T. ; Halonen, A. ; Koistinen, A. ; Koskiaho, P. ; Laukkanen, M. ; Saltevo, J. ; Tiihonen, M. ; Forsen, M. ; Granlund, H. ; Jonsson, A. C. ; Nyroos, B. ; Kinnunen, P. ; Orvola, A. ; Salonen, T. ; Vähänen, A. ; Paldanius, K. R. ; Riihelä, M. ; Ryysy, L. ; Laukkanen, K. H. ; Nyländen, P. ; Sademies, A. ; Anderson, S. ; Asplund, B. ; Byskata, U. ; Liedes, P. ; Kuusela, M. ; Virkkala, T. ; Nikkola, A. ; Ritola, E. ; Niska, T. M. ; Saarinen, H. ; Oukko-Ruponen, S. E. ; Virtanen, T. ; Lyytinen, V. A. ; Kari, P. H. ; Simonen, T. ; Kaprio, S. A. ; Kärkkäinen, J. ; Rantaeskola, B. ; Kääriäinen, T. P. ; Haaga, J. ; Pietiläinen, A. L. ; Klemetti, S. ; Nyandoto, T. ; Rontu, E. ; Satuli-Autere, S. ; Toivonen, K. R. ; Lansimaki, H. V. ; Ahonen, R. ; Ivaska-Suomela, M. ; Jauhiainen, A. ; Laine, M. M. ; Pellonpää, T. ; Puranen, R. ; Airas, M. A. ; Laakso, J. ; Rautavaara, K. ; Erola, R. M. ; Jatkola, E. ; Lönnblad, T. R. ; Malm, A. ; Mäkelä, J. ; Rautamo, E. ; Hentunen, P. ; Lagerstam, J. ; Feodoroff, M. ; Gordin, D. ; Heikkilä, O. ; Hietala, K. ; Fagerudd, J. ; Korolainen, M. ; Kyllönen, L. ; Kytö, J. ; Lindh, S. ; Pettersson-Fernholm, K. ; Rosengård-Bärlund, M. ; Sandelin, A. ; Thorn, L. ; Tuomikangas, J. ; Vesisenaho, T. ; Wadén, J. ; Sipilä, V. ; Kalliomäki, F. T. ; Koskelainen, J. ; Nikkanen, R. ; Savolainen, N. ; Sulonen, H. ; Valtonen, E. ; Norvio, L. ; Hämäläinen, A. ; Toivanen, E. ; Parta, J. A. ; Pirttiniemi, I. ; Aranko, S. ; Ervasti, S. ; Kauppinen-Mäkelin, R. ; Kuusisto, A. ; Leppälä, T. ; Nikkilä, K. ; Pekkonen, L. ; Jokelainen, K. S. ; Kananen, K. ; Karjalainen, M. ; Kemppainen, P. ; Mankinen, A. M. ; Reponen, A. ; Sankari, M. ; Suominen, P. ; Lappalainen, A. ; Liimatainen, M. ; Santaholma, J. ; Aimolahti, A. ; Huovinen, E. ; Ilkka, V. ; Lehtimäki, M. ; Pälikkö-Kontinen, E. ; Vanhanen, A. ; Koskinen, E. ; Siitonen, T. ; Huttunen, E. ; Ikäheimo, R. ; Karhapää, P. ; Kekäläinen, P. ; Laakso, M. ; Lakka, T. ; Lampainen, E. ; Moilanen, L. ; Tanskanen, S. ; Niskanen, L. ; Tuovinen, U. ; Vauhkonen, I. ; Voutilainen, E. ; Huang, Y. ; Lan, H. Y. ; Lok, S. ; Tomlinson, B. ; Tsui, S. K.W. ; Yu, W. ; Yip, K. Y.L. ; Chan, T. F. ; Fan, X. ; Tang, N. ; Tian, X. ; Chan, K. K.H. ; Xie, F. ; Ng, A. C.W. ; Cheung, G. P.Y. ; Yeung, M. W. ; Mai, S. ; Xie, F. ; Zhang, S. ; Yu, P. ; Weng, M. ; Savage, D. A. ; Walker, J. ; Thomas, S. ; Viberti, G. C. ; Boulton, A. J.M. ; Marshall, S. ; Demaine, A. G. ; Millward, B. A. ; Bain, S. C. ; Mäkinen, V. P. ; Ahola, A. J. ; Dahlström, E. ; Gordin, D. ; Heikkilä, O. ; Hietala, K. ; Kytö, J. ; Lehto, M. ; Lithovius, R. ; Panduru, N. M. ; Parkkonen, M. ; Rosengård-Bärlund, M. ; Saraheimo, M. ; Söderlund, J. ; Soro-Paavonen, A. ; Syreeni, A. ; Thorn, L. M. ; Tolonen, N. ; Wadén, J. ; McKay, G. J. ; Isakova, T. ; Guiducci, C. ; Taylor, A. ; Mirel, D. B. ; Williams, W. W. ; Brennan, E. P. ; Sadlier, D. M. ; Martin, F. ; Godson, C. ; Mayer, L. ; Gubitosi-Klug, R. ; Bourne, P. ; Schutta, M. ; Lackaye, M. E. ; Gregory, N. S. ; Kruger, D. ; Jones, J. K. ; Bhan, A. ; Golden, E. ; Aiello, L. ; Larkin, M. ; Nathan, D. ; Ziegler, G. ; Caulder, S. ; Pittman, C. ; Luttrell, L. ; Lopes-Virella, M. ; Johnson, M. ; Gunyou, K. ; Bergenstal, R. ; Vittetoe, B. ; Sivitz, W. ; Flaherty, N. ; Bantle, J. ; Hitt, S. ; Goldstein, D. ; Hainsworth, D. ; Cimino, L. ; Orchard, T. ; Wigley, C. ; Dagogo-Jack, S. ; Strowig, S. ; Raskin, P. ; Barnie, A. ; Zinman, B. ; Fahlstrom, R. ; Palmer, J. ; Harth, J. ; Driscoll, M. ; McDonald, C. ; Lipps Hagan, J. ; May, M. ; Levandoski, L. ; White, N. ; Gatcomb, P. ; Tamborlane, W. ; Adelman, D. ; Colson, S. ; Molitch, M. ; Lorenzi, G. ; Mudaliar, S. ; Johnsonbaugh, S. ; Miller, R. ; Canady, J. ; Schade, D. ; Bernal, M. L. ; Malone, J. ; Morrison, A. ; Martin, C. ; Herman, W. ; Pop-Busui, R. ; Cowie, C. ; Leschek, E. ; Cleary, P. ; Lachin, J. ; Zinman, B. ; Lorenzi, G. ; Braffett, B. ; Steffes, Michael W ; Arends, V. ; Blodi, B. ; Danis, R. ; Lawrence, D. ; Wabers, H. ; Soliman, E. ; Zhang, Z. M. ; Campbell, C. ; Hensley, S. ; Keasler, L. ; Mark, M. ; Albertini, M. ; Boustany, C. ; Ehlgen, A. ; Gerl, M. ; Huber, J. ; Schölch, C. ; Zimdahl-Gelling, H. ; Agardh, E. ; Ajanki, T. ; Al Maghrabi, N. ; Apelqvist, J. ; Bengtsson, E. ; Berglund, L. ; Björckbacka, H. ; Blom-Nilsson, U. ; Borell, M. ; Burström, A. ; Cilio, C. ; Cinthio, M. ; Dreja, K. ; Dunér, P. ; Engelbertsen, D. ; Fadista, J. ; Gomez, M. ; Goncalves, I. ; Hedblad, B. ; Hultgårdh, A. ; Johansson, M. E. ; Kennbäck, C. ; Kravic, J. ; Lernmark, A. ; Lindholm, E. ; Ling, C. ; Luthman, H. ; Neptin, M. ; Nilsson, J. ; Nilsson, P. ; Nilsson, T. ; Nordin, G. ; Ottoson-Laakso, E. ; Persson, A. ; Persson, M. ; Persson, M. A. ; Postma, J. ; Pranter, E. ; Rattik, S. ; Sterner, G. ; Tindberg, L. ; Wigren, M. ; Zetterqvist, A. ; Åkerlund, M. ; Ostling, G. ; Kanninen, T. ; Ahonen-Bishopp, A. ; Eliasson, A. ; Herrala, T. ; Tikka-Kleemola, P. ; Hamsten, A. ; Betsholtz, C. ; Björkholm, A. ; Foroogh, F. ; Genové, G. ; Gertow, K. ; Gigante, B. ; He, B. ; Leander, K. ; McLeod, O. ; Nastase-Mannila, M. ; Patrakka, J. ; Silveira, A. ; Strawbridge, R. ; Tryggvason, K. ; Vikström, M. ; Ohrvik, J. ; Österholm, A. M. ; Thorand, B. ; Gieger, C. ; Grallert, H. ; Ludwig, T. ; Nitz, B. ; Schneider, A. ; Wang-Sattler, R. ; Zierer, A. ; Benigni, A. ; Donadelli, R. ; Lesti, M. D. ; Noris, M. ; Piras, R. ; Ruggenenti, P. ; Chassin, L. ; Dalton, N. ; Deanfield, J. ; Horsford, J. ; Rice, C. ; Rudd, J. ; Walker, N. ; Whitehead, K. ; Wong, M. ; Adams, F. ; Akbar, T. ; Belch, J. ; Dove, F. ; Ellingford, A. ; Farran, B. ; Ferguson, M. ; Henderson, G. ; Houston, G. ; Khan, F. ; Leese, G. ; Livingstone, S. ; Looker, H. ; McCann, M. ; McGurnaghan, S. ; Morris, A. ; Newton, D. ; Pearson, E. ; Reekie, G. ; Smith, N. ; Shore, A. ; Aizawa, K. ; Ball, C. ; Bellenger, N. ; Casanova, F. ; Frayling, T. ; Gates, P. ; Gooding, K. ; Hattersley, A. ; Ling, R. ; Mawson, D. ; Shandas, R. ; Strain, D. ; Thorn, C. ; Smith, U. ; Hammarstedt, A. ; Häring, H. ; Sesti, G. ; Fagerholm, E. ; Parkkonen, M. ; Tolonen, N. ; Toppila, I. ; Salomaa, V. ; Havulinna, A. ; Kristiansson, K. ; Okamo, P. ; Peltola, T. ; Perola, M. ; Pietilä, A. ; Ripatti, S. ; Taimi, M. ; Ylä-Herttuala, S. ; Babu, M. ; Dijkstra, M. ; Gurzeler, E. ; Huusko, J. ; Kholová, I. ; Laakso, M. ; Merentie, M. ; Poikolainen, M. ; Groves, C. ; Juliusdottir, T. ; Karpe, F. ; Lagou, V. ; Morris, A. ; Cobelli, C. ; Di Camillo, B. ; Finotello, Francesca ; Sambo, F. ; Toffolo, G. ; Trifoglio, E. ; Bellazzi, R. ; Barbarini, N. ; Bucalo, M. ; Larizza, C. ; Magni, P. ; Malovini, A. ; Marini, S. ; Mulas, F. ; Quaglini, S. ; Sacchi, L. ; Vitali, F. ; Ferrannini, E. ; Boldrini, B. ; Kozakova, M. ; Mari, A. ; Morizzo, C. ; Mota, L. ; Natali, A. ; Palombo, C. ; Venturi, E. ; Walker, M. ; Patrono, C. ; Pagliaccia, F. ; Rocca, B. ; Nuutila, P. ; Haukkala, J. ; Knuuti, J. ; Roivainen, A. ; Saraste, A. ; McKeague, P. ; Colombo, M. ; Steckel-Hamann, B. ; Bokvist, K. ; Shankar, S. ; Thomas, M. ; Gan, L. M. ; Heinonen, S. ; Jönsson-Rylander, A. C. ; Momo, R. ; Schnecke, V. ; Unwin, R. ; Walentinsson, A. ; Whatling, C. ; Nogoceke, E. ; Pacheco, G. D. ; Formentini, I. ; Schindler, T. ; Tortoli, P. ; Bassi, L. ; Boni, E. ; Dallai, A. ; Guidi, F. ; Lenge, M. ; Matera, R. ; Ramalli, A. ; Ricci, S. ; Viti, J. ; Jablonka, B. ; Crowther, D. ; Gassenhuber, J. ; Hess, S. ; Hubschle, T. ; Juretschke, H. P. ; Rutten, H. ; Sadowski, T. ; Wohlfart, P. ; Clerin, V. ; Hyde, C. ; Malarstig, A. ; Pullen, N. ; Tilley, M. ; Tuthill, T. ; Vangjeli, C. / A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes. In: Diabetes. 2018 ; Vol. 67, No. 7. pp. 1414-1427.
@article{c00f250a316c48a485f69900a2780507,
title = "A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes",
abstract = "Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 3 10 28 ) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.",
author = "{Van Zuydam}, {Natalie R.} and Emma Ahlqvist and Niina Sandholm and Harshal Deshmukh and {William Rayner}, N. and Moustafa Abdalla and Claes Ladenvall and Daniel Ziemek and Eric Fauman and Robertson, {Neil R.} and McKeigue, {Paul M.} and Erkka Valo and Carol Forsblom and Valma Harjutsalo and Annalisa Perna and Erica Rurali and {Loredana Marcovecchio}, M. and Igo, {Robert P.} and Salem, {Rany M.} and Norberto Perico and Maria Lajer and Annemari K{\"a}r{\"a}j{\"a}m{\"a}ki and Minako Imamura and Michiaki Kubo and Atsushi Takahashi and Xueling Sim and Jianjun Liu and {Van Dam}, {Rob M.} and Guozhi Jiang and Tam, {Claudia H.T.} and Luk, {Andrea O.Y.} and Lee, {Heung Man} and Lim, {Cadmon K.P.} and Szeto, {Cheuk Chun} and So, {Wing Yee} and Chan, {Juliana C.N.} and Ang, {Su Fen} and Rajkumar Dorajoo and Ling Wang and Clara, {Tan Si Hua} and McKnight, {Amy Jayne} and Seamus Duffy and Warren and Pezzolesi, {Marcus G.} and Michel Marre and Beata Gyorgy and Samy Hadjadj and Hiraki, {Linda T.} and Ahluwalia, {Tarunveer S.} and Peter Almgren and Schulz, {Christina Alexandra} and Marju Orho-Melander and Allan Linneberg and Cramer Christensen and Witte, {Daniel R.} and Niels Grarup and Ivan Brandslund and Olle Melander and Paterson, {Andrew D.} and David Tregouet and Maxwell, {Alexander P.} and Lim, {Su Chi} and Ma, {Ronald C.W.} and {Shyong Tai}, E. and Shiro Maeda and Valeriya Lyssenko and Tiinamaija Tuomi and Krolewski, {Andrzej S.} and Rich, {Stephen S.} and Hirschhorn, {Joel N.} and Florez, {Jose C.} and David Dunger and Oluf Pedersen and Torben Hansen and Peter Rossing and Giuseppe Remuzzi and Brosnan, {Mary Julia} and Palmer, {Colin N.A.} and Groop, {Per Henrik} and Colhoun, {Helen M.} and Groop, {Leif C.} and McCarthy, {Mark I.} and S. Koivula and T. Uggeldahl and T. Forslund and A. Halonen and A. Koistinen and P. Koskiaho and M. Laukkanen and J. Saltevo and M. Tiihonen and M. Forsen and H. Granlund and Jonsson, {A. C.} and B. Nyroos and P. Kinnunen and A. Orvola and T. Salonen and A. V{\"a}h{\"a}nen and Paldanius, {K. R.} and M. Riihel{\"a} and L. Ryysy and Laukkanen, {K. H.} and P. Nyl{\"a}nden and A. Sademies and S. Anderson and B. Asplund and U. Byskata and P. Liedes and M. Kuusela and T. Virkkala and A. Nikkola and E. Ritola and Niska, {T. M.} and H. Saarinen and Oukko-Ruponen, {S. E.} and T. Virtanen and Lyytinen, {V. A.} and Kari, {P. H.} and T. Simonen and Kaprio, {S. A.} and J. K{\"a}rkk{\"a}inen and B. Rantaeskola and K{\"a}{\"a}ri{\"a}inen, {T. P.} and J. Haaga and Pietil{\"a}inen, {A. L.} and S. Klemetti and T. Nyandoto and E. Rontu and S. Satuli-Autere and Toivonen, {K. R.} and Lansimaki, {H. V.} and R. Ahonen and M. Ivaska-Suomela and A. Jauhiainen and Laine, {M. M.} and T. Pellonp{\"a}{\"a} and R. Puranen and Airas, {M. A.} and J. Laakso and K. Rautavaara and Erola, {R. M.} and E. Jatkola and L{\"o}nnblad, {T. R.} and A. Malm and J. M{\"a}kel{\"a} and E. Rautamo and P. Hentunen and J. Lagerstam and M. Feodoroff and D. Gordin and O. Heikkil{\"a} and K. Hietala and J. Fagerudd and M. Korolainen and L. Kyll{\"o}nen and J. Kyt{\"o} and S. Lindh and K. Pettersson-Fernholm and M. Roseng{\aa}rd-B{\"a}rlund and A. Sandelin and L. Thorn and J. Tuomikangas and T. Vesisenaho and J. Wad{\'e}n and V. Sipil{\"a} and Kalliom{\"a}ki, {F. T.} and J. Koskelainen and R. Nikkanen and N. Savolainen and H. Sulonen and E. Valtonen and L. Norvio and A. H{\"a}m{\"a}l{\"a}inen and E. Toivanen and Parta, {J. A.} and I. Pirttiniemi and S. Aranko and S. Ervasti and R. Kauppinen-M{\"a}kelin and A. Kuusisto and T. Lepp{\"a}l{\"a} and K. Nikkil{\"a} and L. Pekkonen and Jokelainen, {K. S.} and K. Kananen and M. Karjalainen and P. Kemppainen and Mankinen, {A. M.} and A. Reponen and M. Sankari and P. Suominen and A. Lappalainen and M. Liimatainen and J. Santaholma and A. Aimolahti and E. Huovinen and V. Ilkka and M. Lehtim{\"a}ki and E. P{\"a}likk{\"o}-Kontinen and A. Vanhanen and E. Koskinen and T. Siitonen and E. Huttunen and R. Ik{\"a}heimo and P. Karhap{\"a}{\"a} and P. Kek{\"a}l{\"a}inen and M. Laakso and T. Lakka and E. Lampainen and L. Moilanen and S. Tanskanen and L. Niskanen and U. Tuovinen and I. Vauhkonen and E. Voutilainen and Y. Huang and Lan, {H. Y.} and S. Lok and B. Tomlinson and Tsui, {S. K.W.} and W. Yu and Yip, {K. Y.L.} and Chan, {T. F.} and X. Fan and N. Tang and X. Tian and Chan, {K. K.H.} and F. Xie and Ng, {A. C.W.} and Cheung, {G. P.Y.} and Yeung, {M. W.} and S. Mai and F. Xie and S. Zhang and P. Yu and M. Weng and Savage, {D. A.} and J. Walker and S. Thomas and Viberti, {G. C.} and Boulton, {A. J.M.} and S. Marshall and Demaine, {A. G.} and Millward, {B. A.} and Bain, {S. C.} and M{\"a}kinen, {V. P.} and Ahola, {A. J.} and E. Dahlstr{\"o}m and D. Gordin and O. Heikkil{\"a} and K. Hietala and J. Kyt{\"o} and M. Lehto and R. Lithovius and Panduru, {N. M.} and M. Parkkonen and M. Roseng{\aa}rd-B{\"a}rlund and M. Saraheimo and J. S{\"o}derlund and A. Soro-Paavonen and A. Syreeni and Thorn, {L. M.} and N. Tolonen and J. Wad{\'e}n and McKay, {G. J.} and T. Isakova and C. Guiducci and A. Taylor and Mirel, {D. B.} and Williams, {W. W.} and Brennan, {E. P.} and Sadlier, {D. M.} and F. Martin and C. Godson and L. Mayer and R. Gubitosi-Klug and P. Bourne and M. Schutta and Lackaye, {M. E.} and Gregory, {N. S.} and D. Kruger and Jones, {J. K.} and A. Bhan and E. Golden and L. Aiello and M. Larkin and D. Nathan and G. Ziegler and S. Caulder and C. Pittman and L. Luttrell and M. Lopes-Virella and M. Johnson and K. Gunyou and R. Bergenstal and B. Vittetoe and W. Sivitz and N. Flaherty and J. Bantle and S. Hitt and D. Goldstein and D. Hainsworth and L. Cimino and T. Orchard and C. Wigley and S. Dagogo-Jack and S. Strowig and P. Raskin and A. Barnie and B. Zinman and R. Fahlstrom and J. Palmer and J. Harth and M. Driscoll and C. McDonald and {Lipps Hagan}, J. and M. May and L. Levandoski and N. White and P. Gatcomb and W. Tamborlane and D. Adelman and S. Colson and M. Molitch and G. Lorenzi and S. Mudaliar and S. Johnsonbaugh and R. Miller and J. Canady and D. Schade and Bernal, {M. L.} and J. Malone and A. Morrison and C. Martin and W. Herman and R. Pop-Busui and C. Cowie and E. Leschek and P. Cleary and J. Lachin and B. Zinman and G. Lorenzi and B. Braffett and Steffes, {Michael W} and V. Arends and B. Blodi and R. Danis and D. Lawrence and H. Wabers and E. Soliman and Zhang, {Z. M.} and C. Campbell and S. Hensley and L. Keasler and M. Mark and M. Albertini and C. Boustany and A. Ehlgen and M. Gerl and J. Huber and C. Sch{\"o}lch and H. Zimdahl-Gelling and E. Agardh and T. Ajanki and {Al Maghrabi}, N. and J. Apelqvist and E. Bengtsson and L. Berglund and H. Bj{\"o}rckbacka and U. Blom-Nilsson and M. Borell and A. Burstr{\"o}m and C. Cilio and M. Cinthio and K. Dreja and P. Dun{\'e}r and D. Engelbertsen and J. Fadista and M. Gomez and I. Goncalves and B. Hedblad and A. Hultg{\aa}rdh and Johansson, {M. E.} and C. Kennb{\"a}ck and J. Kravic and A. Lernmark and E. Lindholm and C. Ling and H. Luthman and M. Neptin and J. Nilsson and P. Nilsson and T. Nilsson and G. Nordin and E. Ottoson-Laakso and A. Persson and M. Persson and Persson, {M. A.} and J. Postma and E. Pranter and S. Rattik and G. Sterner and L. Tindberg and M. Wigren and A. Zetterqvist and M. {\AA}kerlund and G. Ostling and T. Kanninen and A. Ahonen-Bishopp and A. Eliasson and T. Herrala and P. Tikka-Kleemola and A. Hamsten and C. Betsholtz and A. Bj{\"o}rkholm and F. Foroogh and G. Genov{\'e} and K. Gertow and B. Gigante and B. He and K. Leander and O. McLeod and M. Nastase-Mannila and J. Patrakka and A. Silveira and R. Strawbridge and K. Tryggvason and M. Vikstr{\"o}m and J. Ohrvik and {\"O}sterholm, {A. M.} and B. Thorand and C. Gieger and H. Grallert and T. Ludwig and B. Nitz and A. Schneider and R. Wang-Sattler and A. Zierer and A. Benigni and R. Donadelli and Lesti, {M. D.} and M. Noris and R. Piras and P. Ruggenenti and L. Chassin and N. Dalton and J. Deanfield and J. Horsford and C. Rice and J. Rudd and N. Walker and K. Whitehead and M. Wong and F. Adams and T. Akbar and J. Belch and F. Dove and A. Ellingford and B. Farran and M. Ferguson and G. Henderson and G. Houston and F. Khan and G. Leese and S. Livingstone and H. Looker and M. McCann and S. McGurnaghan and A. Morris and D. Newton and E. Pearson and G. Reekie and N. Smith and A. Shore and K. Aizawa and C. Ball and N. Bellenger and F. Casanova and T. Frayling and P. Gates and K. Gooding and A. Hattersley and R. Ling and D. Mawson and R. Shandas and D. Strain and C. Thorn and U. Smith and A. Hammarstedt and H. H{\"a}ring and G. Sesti and E. Fagerholm and M. Parkkonen and N. Tolonen and I. Toppila and V. Salomaa and A. Havulinna and K. Kristiansson and P. Okamo and T. Peltola and M. Perola and A. Pietil{\"a} and S. Ripatti and M. Taimi and S. Yl{\"a}-Herttuala and M. Babu and M. Dijkstra and E. Gurzeler and J. Huusko and I. Kholov{\'a} and M. Laakso and M. Merentie and M. Poikolainen and C. Groves and T. Juliusdottir and F. Karpe and V. Lagou and A. Morris and C. Cobelli and {Di Camillo}, B. and Francesca Finotello and F. Sambo and G. Toffolo and E. Trifoglio and R. Bellazzi and N. Barbarini and M. Bucalo and C. Larizza and P. Magni and A. Malovini and S. Marini and F. Mulas and S. Quaglini and L. Sacchi and F. Vitali and E. Ferrannini and B. Boldrini and M. Kozakova and A. Mari and C. Morizzo and L. Mota and A. Natali and C. Palombo and E. Venturi and M. Walker and C. Patrono and F. Pagliaccia and B. Rocca and P. Nuutila and J. Haukkala and J. Knuuti and A. Roivainen and A. Saraste and P. McKeague and M. Colombo and B. Steckel-Hamann and K. Bokvist and S. Shankar and M. Thomas and Gan, {L. M.} and S. Heinonen and J{\"o}nsson-Rylander, {A. C.} and R. Momo and V. Schnecke and R. Unwin and A. Walentinsson and C. Whatling and E. Nogoceke and Pacheco, {G. D.} and I. Formentini and T. Schindler and P. Tortoli and L. Bassi and E. Boni and A. Dallai and F. Guidi and M. Lenge and R. Matera and A. Ramalli and S. Ricci and J. Viti and B. Jablonka and D. Crowther and J. Gassenhuber and S. Hess and T. Hubschle and Juretschke, {H. P.} and H. Rutten and T. Sadowski and P. Wohlfart and V. Clerin and C. Hyde and A. Malarstig and N. Pullen and M. Tilley and T. Tuthill and C. Vangjeli",
year = "2018",
month = "7",
day = "1",
doi = "10.2337/db17-0914",
language = "English (US)",
volume = "67",
pages = "1414--1427",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "7",

}

TY - JOUR

T1 - A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes

AU - Van Zuydam, Natalie R.

AU - Ahlqvist, Emma

AU - Sandholm, Niina

AU - Deshmukh, Harshal

AU - William Rayner, N.

AU - Abdalla, Moustafa

AU - Ladenvall, Claes

AU - Ziemek, Daniel

AU - Fauman, Eric

AU - Robertson, Neil R.

AU - McKeigue, Paul M.

AU - Valo, Erkka

AU - Forsblom, Carol

AU - Harjutsalo, Valma

AU - Perna, Annalisa

AU - Rurali, Erica

AU - Loredana Marcovecchio, M.

AU - Igo, Robert P.

AU - Salem, Rany M.

AU - Perico, Norberto

AU - Lajer, Maria

AU - Käräjämäki, Annemari

AU - Imamura, Minako

AU - Kubo, Michiaki

AU - Takahashi, Atsushi

AU - Sim, Xueling

AU - Liu, Jianjun

AU - Van Dam, Rob M.

AU - Jiang, Guozhi

AU - Tam, Claudia H.T.

AU - Luk, Andrea O.Y.

AU - Lee, Heung Man

AU - Lim, Cadmon K.P.

AU - Szeto, Cheuk Chun

AU - So, Wing Yee

AU - Chan, Juliana C.N.

AU - Ang, Su Fen

AU - Dorajoo, Rajkumar

AU - Wang, Ling

AU - Clara, Tan Si Hua

AU - McKnight, Amy Jayne

AU - Duffy, Seamus

AU - Warren,

AU - Pezzolesi, Marcus G.

AU - Marre, Michel

AU - Gyorgy, Beata

AU - Hadjadj, Samy

AU - Hiraki, Linda T.

AU - Ahluwalia, Tarunveer S.

AU - Almgren, Peter

AU - Schulz, Christina Alexandra

AU - Orho-Melander, Marju

AU - Linneberg, Allan

AU - Christensen, Cramer

AU - Witte, Daniel R.

AU - Grarup, Niels

AU - Brandslund, Ivan

AU - Melander, Olle

AU - Paterson, Andrew D.

AU - Tregouet, David

AU - Maxwell, Alexander P.

AU - Lim, Su Chi

AU - Ma, Ronald C.W.

AU - Shyong Tai, E.

AU - Maeda, Shiro

AU - Lyssenko, Valeriya

AU - Tuomi, Tiinamaija

AU - Krolewski, Andrzej S.

AU - Rich, Stephen S.

AU - Hirschhorn, Joel N.

AU - Florez, Jose C.

AU - Dunger, David

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Rossing, Peter

AU - Remuzzi, Giuseppe

AU - Brosnan, Mary Julia

AU - Palmer, Colin N.A.

AU - Groop, Per Henrik

AU - Colhoun, Helen M.

AU - Groop, Leif C.

AU - McCarthy, Mark I.

AU - Koivula, S.

AU - Uggeldahl, T.

AU - Forslund, T.

AU - Halonen, A.

AU - Koistinen, A.

AU - Koskiaho, P.

AU - Laukkanen, M.

AU - Saltevo, J.

AU - Tiihonen, M.

AU - Forsen, M.

AU - Granlund, H.

AU - Jonsson, A. C.

AU - Nyroos, B.

AU - Kinnunen, P.

AU - Orvola, A.

AU - Salonen, T.

AU - Vähänen, A.

AU - Paldanius, K. R.

AU - Riihelä, M.

AU - Ryysy, L.

AU - Laukkanen, K. H.

AU - Nyländen, P.

AU - Sademies, A.

AU - Anderson, S.

AU - Asplund, B.

AU - Byskata, U.

AU - Liedes, P.

AU - Kuusela, M.

AU - Virkkala, T.

AU - Nikkola, A.

AU - Ritola, E.

AU - Niska, T. M.

AU - Saarinen, H.

AU - Oukko-Ruponen, S. E.

AU - Virtanen, T.

AU - Lyytinen, V. A.

AU - Kari, P. H.

AU - Simonen, T.

AU - Kaprio, S. A.

AU - Kärkkäinen, J.

AU - Rantaeskola, B.

AU - Kääriäinen, T. P.

AU - Haaga, J.

AU - Pietiläinen, A. L.

AU - Klemetti, S.

AU - Nyandoto, T.

AU - Rontu, E.

AU - Satuli-Autere, S.

AU - Toivonen, K. R.

AU - Lansimaki, H. V.

AU - Ahonen, R.

AU - Ivaska-Suomela, M.

AU - Jauhiainen, A.

AU - Laine, M. M.

AU - Pellonpää, T.

AU - Puranen, R.

AU - Airas, M. A.

AU - Laakso, J.

AU - Rautavaara, K.

AU - Erola, R. M.

AU - Jatkola, E.

AU - Lönnblad, T. R.

AU - Malm, A.

AU - Mäkelä, J.

AU - Rautamo, E.

AU - Hentunen, P.

AU - Lagerstam, J.

AU - Feodoroff, M.

AU - Gordin, D.

AU - Heikkilä, O.

AU - Hietala, K.

AU - Fagerudd, J.

AU - Korolainen, M.

AU - Kyllönen, L.

AU - Kytö, J.

AU - Lindh, S.

AU - Pettersson-Fernholm, K.

AU - Rosengård-Bärlund, M.

AU - Sandelin, A.

AU - Thorn, L.

AU - Tuomikangas, J.

AU - Vesisenaho, T.

AU - Wadén, J.

AU - Sipilä, V.

AU - Kalliomäki, F. T.

AU - Koskelainen, J.

AU - Nikkanen, R.

AU - Savolainen, N.

AU - Sulonen, H.

AU - Valtonen, E.

AU - Norvio, L.

AU - Hämäläinen, A.

AU - Toivanen, E.

AU - Parta, J. A.

AU - Pirttiniemi, I.

AU - Aranko, S.

AU - Ervasti, S.

AU - Kauppinen-Mäkelin, R.

AU - Kuusisto, A.

AU - Leppälä, T.

AU - Nikkilä, K.

AU - Pekkonen, L.

AU - Jokelainen, K. S.

AU - Kananen, K.

AU - Karjalainen, M.

AU - Kemppainen, P.

AU - Mankinen, A. M.

AU - Reponen, A.

AU - Sankari, M.

AU - Suominen, P.

AU - Lappalainen, A.

AU - Liimatainen, M.

AU - Santaholma, J.

AU - Aimolahti, A.

AU - Huovinen, E.

AU - Ilkka, V.

AU - Lehtimäki, M.

AU - Pälikkö-Kontinen, E.

AU - Vanhanen, A.

AU - Koskinen, E.

AU - Siitonen, T.

AU - Huttunen, E.

AU - Ikäheimo, R.

AU - Karhapää, P.

AU - Kekäläinen, P.

AU - Laakso, M.

AU - Lakka, T.

AU - Lampainen, E.

AU - Moilanen, L.

AU - Tanskanen, S.

AU - Niskanen, L.

AU - Tuovinen, U.

AU - Vauhkonen, I.

AU - Voutilainen, E.

AU - Huang, Y.

AU - Lan, H. Y.

AU - Lok, S.

AU - Tomlinson, B.

AU - Tsui, S. K.W.

AU - Yu, W.

AU - Yip, K. Y.L.

AU - Chan, T. F.

AU - Fan, X.

AU - Tang, N.

AU - Tian, X.

AU - Chan, K. K.H.

AU - Xie, F.

AU - Ng, A. C.W.

AU - Cheung, G. P.Y.

AU - Yeung, M. W.

AU - Mai, S.

AU - Xie, F.

AU - Zhang, S.

AU - Yu, P.

AU - Weng, M.

AU - Savage, D. A.

AU - Walker, J.

AU - Thomas, S.

AU - Viberti, G. C.

AU - Boulton, A. J.M.

AU - Marshall, S.

AU - Demaine, A. G.

AU - Millward, B. A.

AU - Bain, S. C.

AU - Mäkinen, V. P.

AU - Ahola, A. J.

AU - Dahlström, E.

AU - Gordin, D.

AU - Heikkilä, O.

AU - Hietala, K.

AU - Kytö, J.

AU - Lehto, M.

AU - Lithovius, R.

AU - Panduru, N. M.

AU - Parkkonen, M.

AU - Rosengård-Bärlund, M.

AU - Saraheimo, M.

AU - Söderlund, J.

AU - Soro-Paavonen, A.

AU - Syreeni, A.

AU - Thorn, L. M.

AU - Tolonen, N.

AU - Wadén, J.

AU - McKay, G. J.

AU - Isakova, T.

AU - Guiducci, C.

AU - Taylor, A.

AU - Mirel, D. B.

AU - Williams, W. W.

AU - Brennan, E. P.

AU - Sadlier, D. M.

AU - Martin, F.

AU - Godson, C.

AU - Mayer, L.

AU - Gubitosi-Klug, R.

AU - Bourne, P.

AU - Schutta, M.

AU - Lackaye, M. E.

AU - Gregory, N. S.

AU - Kruger, D.

AU - Jones, J. K.

AU - Bhan, A.

AU - Golden, E.

AU - Aiello, L.

AU - Larkin, M.

AU - Nathan, D.

AU - Ziegler, G.

AU - Caulder, S.

AU - Pittman, C.

AU - Luttrell, L.

AU - Lopes-Virella, M.

AU - Johnson, M.

AU - Gunyou, K.

AU - Bergenstal, R.

AU - Vittetoe, B.

AU - Sivitz, W.

AU - Flaherty, N.

AU - Bantle, J.

AU - Hitt, S.

AU - Goldstein, D.

AU - Hainsworth, D.

AU - Cimino, L.

AU - Orchard, T.

AU - Wigley, C.

AU - Dagogo-Jack, S.

AU - Strowig, S.

AU - Raskin, P.

AU - Barnie, A.

AU - Zinman, B.

AU - Fahlstrom, R.

AU - Palmer, J.

AU - Harth, J.

AU - Driscoll, M.

AU - McDonald, C.

AU - Lipps Hagan, J.

AU - May, M.

AU - Levandoski, L.

AU - White, N.

AU - Gatcomb, P.

AU - Tamborlane, W.

AU - Adelman, D.

AU - Colson, S.

AU - Molitch, M.

AU - Lorenzi, G.

AU - Mudaliar, S.

AU - Johnsonbaugh, S.

AU - Miller, R.

AU - Canady, J.

AU - Schade, D.

AU - Bernal, M. L.

AU - Malone, J.

AU - Morrison, A.

AU - Martin, C.

AU - Herman, W.

AU - Pop-Busui, R.

AU - Cowie, C.

AU - Leschek, E.

AU - Cleary, P.

AU - Lachin, J.

AU - Zinman, B.

AU - Lorenzi, G.

AU - Braffett, B.

AU - Steffes, Michael W

AU - Arends, V.

AU - Blodi, B.

AU - Danis, R.

AU - Lawrence, D.

AU - Wabers, H.

AU - Soliman, E.

AU - Zhang, Z. M.

AU - Campbell, C.

AU - Hensley, S.

AU - Keasler, L.

AU - Mark, M.

AU - Albertini, M.

AU - Boustany, C.

AU - Ehlgen, A.

AU - Gerl, M.

AU - Huber, J.

AU - Schölch, C.

AU - Zimdahl-Gelling, H.

AU - Agardh, E.

AU - Ajanki, T.

AU - Al Maghrabi, N.

AU - Apelqvist, J.

AU - Bengtsson, E.

AU - Berglund, L.

AU - Björckbacka, H.

AU - Blom-Nilsson, U.

AU - Borell, M.

AU - Burström, A.

AU - Cilio, C.

AU - Cinthio, M.

AU - Dreja, K.

AU - Dunér, P.

AU - Engelbertsen, D.

AU - Fadista, J.

AU - Gomez, M.

AU - Goncalves, I.

AU - Hedblad, B.

AU - Hultgårdh, A.

AU - Johansson, M. E.

AU - Kennbäck, C.

AU - Kravic, J.

AU - Lernmark, A.

AU - Lindholm, E.

AU - Ling, C.

AU - Luthman, H.

AU - Neptin, M.

AU - Nilsson, J.

AU - Nilsson, P.

AU - Nilsson, T.

AU - Nordin, G.

AU - Ottoson-Laakso, E.

AU - Persson, A.

AU - Persson, M.

AU - Persson, M. A.

AU - Postma, J.

AU - Pranter, E.

AU - Rattik, S.

AU - Sterner, G.

AU - Tindberg, L.

AU - Wigren, M.

AU - Zetterqvist, A.

AU - Åkerlund, M.

AU - Ostling, G.

AU - Kanninen, T.

AU - Ahonen-Bishopp, A.

AU - Eliasson, A.

AU - Herrala, T.

AU - Tikka-Kleemola, P.

AU - Hamsten, A.

AU - Betsholtz, C.

AU - Björkholm, A.

AU - Foroogh, F.

AU - Genové, G.

AU - Gertow, K.

AU - Gigante, B.

AU - He, B.

AU - Leander, K.

AU - McLeod, O.

AU - Nastase-Mannila, M.

AU - Patrakka, J.

AU - Silveira, A.

AU - Strawbridge, R.

AU - Tryggvason, K.

AU - Vikström, M.

AU - Ohrvik, J.

AU - Österholm, A. M.

AU - Thorand, B.

AU - Gieger, C.

AU - Grallert, H.

AU - Ludwig, T.

AU - Nitz, B.

AU - Schneider, A.

AU - Wang-Sattler, R.

AU - Zierer, A.

AU - Benigni, A.

AU - Donadelli, R.

AU - Lesti, M. D.

AU - Noris, M.

AU - Piras, R.

AU - Ruggenenti, P.

AU - Chassin, L.

AU - Dalton, N.

AU - Deanfield, J.

AU - Horsford, J.

AU - Rice, C.

AU - Rudd, J.

AU - Walker, N.

AU - Whitehead, K.

AU - Wong, M.

AU - Adams, F.

AU - Akbar, T.

AU - Belch, J.

AU - Dove, F.

AU - Ellingford, A.

AU - Farran, B.

AU - Ferguson, M.

AU - Henderson, G.

AU - Houston, G.

AU - Khan, F.

AU - Leese, G.

AU - Livingstone, S.

AU - Looker, H.

AU - McCann, M.

AU - McGurnaghan, S.

AU - Morris, A.

AU - Newton, D.

AU - Pearson, E.

AU - Reekie, G.

AU - Smith, N.

AU - Shore, A.

AU - Aizawa, K.

AU - Ball, C.

AU - Bellenger, N.

AU - Casanova, F.

AU - Frayling, T.

AU - Gates, P.

AU - Gooding, K.

AU - Hattersley, A.

AU - Ling, R.

AU - Mawson, D.

AU - Shandas, R.

AU - Strain, D.

AU - Thorn, C.

AU - Smith, U.

AU - Hammarstedt, A.

AU - Häring, H.

AU - Sesti, G.

AU - Fagerholm, E.

AU - Parkkonen, M.

AU - Tolonen, N.

AU - Toppila, I.

AU - Salomaa, V.

AU - Havulinna, A.

AU - Kristiansson, K.

AU - Okamo, P.

AU - Peltola, T.

AU - Perola, M.

AU - Pietilä, A.

AU - Ripatti, S.

AU - Taimi, M.

AU - Ylä-Herttuala, S.

AU - Babu, M.

AU - Dijkstra, M.

AU - Gurzeler, E.

AU - Huusko, J.

AU - Kholová, I.

AU - Laakso, M.

AU - Merentie, M.

AU - Poikolainen, M.

AU - Groves, C.

AU - Juliusdottir, T.

AU - Karpe, F.

AU - Lagou, V.

AU - Morris, A.

AU - Cobelli, C.

AU - Di Camillo, B.

AU - Finotello, Francesca

AU - Sambo, F.

AU - Toffolo, G.

AU - Trifoglio, E.

AU - Bellazzi, R.

AU - Barbarini, N.

AU - Bucalo, M.

AU - Larizza, C.

AU - Magni, P.

AU - Malovini, A.

AU - Marini, S.

AU - Mulas, F.

AU - Quaglini, S.

AU - Sacchi, L.

AU - Vitali, F.

AU - Ferrannini, E.

AU - Boldrini, B.

AU - Kozakova, M.

AU - Mari, A.

AU - Morizzo, C.

AU - Mota, L.

AU - Natali, A.

AU - Palombo, C.

AU - Venturi, E.

AU - Walker, M.

AU - Patrono, C.

AU - Pagliaccia, F.

AU - Rocca, B.

AU - Nuutila, P.

AU - Haukkala, J.

AU - Knuuti, J.

AU - Roivainen, A.

AU - Saraste, A.

AU - McKeague, P.

AU - Colombo, M.

AU - Steckel-Hamann, B.

AU - Bokvist, K.

AU - Shankar, S.

AU - Thomas, M.

AU - Gan, L. M.

AU - Heinonen, S.

AU - Jönsson-Rylander, A. C.

AU - Momo, R.

AU - Schnecke, V.

AU - Unwin, R.

AU - Walentinsson, A.

AU - Whatling, C.

AU - Nogoceke, E.

AU - Pacheco, G. D.

AU - Formentini, I.

AU - Schindler, T.

AU - Tortoli, P.

AU - Bassi, L.

AU - Boni, E.

AU - Dallai, A.

AU - Guidi, F.

AU - Lenge, M.

AU - Matera, R.

AU - Ramalli, A.

AU - Ricci, S.

AU - Viti, J.

AU - Jablonka, B.

AU - Crowther, D.

AU - Gassenhuber, J.

AU - Hess, S.

AU - Hubschle, T.

AU - Juretschke, H. P.

AU - Rutten, H.

AU - Sadowski, T.

AU - Wohlfart, P.

AU - Clerin, V.

AU - Hyde, C.

AU - Malarstig, A.

AU - Pullen, N.

AU - Tilley, M.

AU - Tuthill, T.

AU - Vangjeli, C.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 3 10 28 ) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.

AB - Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 3 10 28 ) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.

UR - http://www.scopus.com/inward/record.url?scp=85048828771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048828771&partnerID=8YFLogxK

U2 - 10.2337/db17-0914

DO - 10.2337/db17-0914

M3 - Article

C2 - 29703844

AN - SCOPUS:85048828771

VL - 67

SP - 1414

EP - 1427

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 7

ER -