A G protein-based model of adaptation in Dictyostelium discoideum

Yuanhua Tang, Hans G. Othmer

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


A new model is proposed based on signal transduction via G proteins for adaptation of the signal relay process in the cellular slime mold Dictyostelium discoideum. The kinetic constants involved in the model are estimated from Dictyostelium discoideum and other systems. A qualitative analysis of the model shows how adaptation arises, and numerical computations show that the model agrees with observations in both perfusion and suspension experiments. Several experiments that can serve to test the model are suggested.

Original languageEnglish (US)
Pages (from-to)25-76
Number of pages52
JournalMathematical Biosciences
Issue number1
StatePublished - Mar 1994
Externally publishedYes

Bibliographical note

Funding Information:
This mechanism is supported by several facts. l It is found in other systems that an increase in the GTP concentration causes a decrease in the concentration of the H,R, complex but has little effect on the HiRi complex [27, 311. In our mechanism the decrease in [H,R,l due to the increase in [GTPI is mediated through the increase in [G[]. The formation of H,R,G{ and its rapid decomposition leads to a decrease in the concentration of the H,R, complex. l The affinity of R, for H, is decreased in the presence of GI [31, 491.I n the proposed scheme this results from the rapid decomposition of the H,R,GI complex.


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