Abstract
A new model is proposed based on signal transduction via G proteins for adaptation of the signal relay process in the cellular slime mold Dictyostelium discoideum. The kinetic constants involved in the model are estimated from Dictyostelium discoideum and other systems. A qualitative analysis of the model shows how adaptation arises, and numerical computations show that the model agrees with observations in both perfusion and suspension experiments. Several experiments that can serve to test the model are suggested.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25-76 |
| Number of pages | 52 |
| Journal | Mathematical Biosciences |
| Volume | 120 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1994 |
| Externally published | Yes |
Bibliographical note
Funding Information:This mechanism is supported by several facts. l It is found in other systems that an increase in the GTP concentration causes a decrease in the concentration of the H,R, complex but has little effect on the HiRi complex [27, 311. In our mechanism the decrease in [H,R,l due to the increase in [GTPI is mediated through the increase in [G[]. The formation of H,R,G{ and its rapid decomposition leads to a decrease in the concentration of the H,R, complex. l The affinity of R, for H, is decreased in the presence of GI [31, 491.I n the proposed scheme this results from the rapid decomposition of the H,R,GI complex.