A-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity

Keyphrases

• Alkynes 100%
• Analogue Peptide 14%
• Azides 100%
• Bioactivity 100%
• Biological Activity 14%
• Bioorthogonal 14%
• C-terminus 14%
• Cysteine 14%
• Data Interpretation 14%
• Disease Model 14%
• Dodecapeptide 14%
• Enzymatic Steps 14%
• Farnesyl Pyrophosphate 14%
• Geranylgeranyl Pyrophosphate 14%
• Human Factors 100%
• Isoprenoids 100%
• Labeling Experiment 42%
• Metabolic Labeling 42%
• Methyl Ester 14%
• Methyltransferase 14%
• Natural Lipids 14%
• Physiological Changes 14%
• Post-translational Modification 14%
• Precursor Peptide 28%
• Prenylated Proteins 42%
• Prenylation 28%
• Protease 14%
• Protein Prenylation 28%
• Rce1 14%
• Ste24 14%
• Step Processes 14%
• Substructure 14%

Biochemistry, Genetics and Molecular Biology

• Biological Activity 100%
• C-Terminus 100%
• Cysteine 50%
• Geranylgeranyl Pyrophosphate 50%
• Lipid 50%
• Methyltransferase 50%
• Posttranslational Modification 50%
• Precursor 100%
• Protease 50%
• Protein Prenylation 100%
• Pyrophosphate 50%
• Wild Type 100%

Neuroscience

• Alkyne 100%
• Azide 100%
• C-Terminus 33%
• Farnesyl Diphosphate 16%
• Geranylgeranyl Pyrophosphate 16%
• Isoprenoid 100%
• Mecysteine 16%
• Methyltransferase 16%
• Posttranslational Modification 16%
• Protein Prenylation 33%
• Proteinase 16%