The resin-bound cyclic malonic acid ester 2 reacted with aryl isothiocyanate and alkyl halides to afford the key intermediate arylthioaminomethylene cyclic malonic ester resin 3. Subsequently, resin 3 proceeded thermal cydization giving the 2-alkylthio-4(1H)-quinolones in good yields and excellent purities.
|Original language||English (US)|
|Number of pages||3|
|Journal||Chinese Journal of Chemistry|
|State||Published - May 1 2003|
- Resin-bound cyclic malonic acid ester
- Solid-phase synthesis