A Facile One-Pot Synthesis of Symmetrical and Unsymmetrical Acetaldehyde Acetals from Primary Alcohols

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Abstract

Initial formation of a vinyl ether 2 by treatment of a primary alcohol 1 with ethyl vinyl ether in the presence of mercury (II) acetate followed by treatment with the same or a different alcohol in the presence of p-toluenesulfonic acid affords the symmetrical and unsymmetrical acetaldehyde acetals 3 in good overall yield. The method is easily scaled up and represents a significant improvement over currently available procedures.

Original languageEnglish (US)
Pages (from-to)687-692
Number of pages6
JournalSynthetic Communications
Volume22
Issue number5
DOIs
StatePublished - Mar 1 1992
Externally publishedYes

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