A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a 'volatilizable' support

Yangmei Li; Marc Giulianotti; Richard A. Houghten

doi:10.1016/j.tetlet.2010.08.026

A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a 'volatilizable' support

Yangmei Li, Marc Giulianotti, Richard A. Houghten

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A facile solid-phase synthetic approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives was reported. Functionalized aminomethylphenyl silica gel was used as a 'volatilizable' support. The products were cleaved with 10% HF and were obtained in high yields and purities.

Original language	English (US)
Pages (from-to)	5637-5639
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	43
DOIs	https://doi.org/10.1016/j.tetlet.2010.08.026
State	Published - Oct 2 2010
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the State of Florida, Executive Officer of the Governor’s Office of Tourism, Trade and Economic Development, National Science Foundation (R.A.H. CHE 0455072), 1P41GM079590, 1P41GM081261, and U54HG03916-MLSCN.

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10.1016/j.tetlet.2010.08.026

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title = "A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a 'volatilizable' support",

abstract = "A facile solid-phase synthetic approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives was reported. Functionalized aminomethylphenyl silica gel was used as a 'volatilizable' support. The products were cleaved with 10% HF and were obtained in high yields and purities.",

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AU - Li, Yangmei

AU - Giulianotti, Marc

AU - Houghten, Richard A.

N1 - Funding Information: This work was supported by the State of Florida, Executive Officer of the Governor’s Office of Tourism, Trade and Economic Development, National Science Foundation (R.A.H. CHE 0455072), 1P41GM079590, 1P41GM081261, and U54HG03916-MLSCN.

PY - 2010/10/2

Y1 - 2010/10/2

N2 - A facile solid-phase synthetic approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives was reported. Functionalized aminomethylphenyl silica gel was used as a 'volatilizable' support. The products were cleaved with 10% HF and were obtained in high yields and purities.

AB - A facile solid-phase synthetic approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives was reported. Functionalized aminomethylphenyl silica gel was used as a 'volatilizable' support. The products were cleaved with 10% HF and were obtained in high yields and purities.

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M3 - Article

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SP - 5637

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a 'volatilizable' support

Abstract

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