A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and vinyl azides

Hongbin Zou; Huajian Zhu; Jiaan Shao; Jianwei Wu; Wenteng Chen; Marc A. Giulianotti; Yongping Yu

doi:10.1016/j.tet.2011.04.103

A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and vinyl azides

Hongbin Zou, Huajian Zhu, Jiaan Shao, Jianwei Wu, Wenteng Chen, Marc A. Giulianotti, Yongping Yu

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A novel and facile approach to polysubstituted pyrazoles from readily synthesized hydrazonyl chlorides and vinyl azides was developed. The reaction was regiospecific and proceeded under mild conditions in the presence of base.

Original language	English (US)
Pages (from-to)	4887-4891
Number of pages	5
Journal	Tetrahedron
Volume	67
Issue number	26
DOIs	https://doi.org/10.1016/j.tet.2011.04.103
State	Published - Jul 1 2011
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported by the National Natural Science Foundation of China (No. 20802066 ), National Science & Technology Major Project ‘Key New Drug Creation and Manufacturing Program’ of China (No. 2009ZX09501-010 ) and the China Postdoctoral Science Foundation . We would like to give our great thanks to Mr. Jianming Gu for his help with the X-ray crystallographic analysis.

Keywords

Hydrazonyl chlorides
Polysubstituted pyrazoles
Regiospecific approach
Vinyl azides
X-ray structure

Publisher link

10.1016/j.tet.2011.04.103

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title = "A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and vinyl azides",

abstract = "A novel and facile approach to polysubstituted pyrazoles from readily synthesized hydrazonyl chlorides and vinyl azides was developed. The reaction was regiospecific and proceeded under mild conditions in the presence of base.",

keywords = "Hydrazonyl chlorides, Polysubstituted pyrazoles, Regiospecific approach, Vinyl azides, X-ray structure",

author = "Hongbin Zou and Huajian Zhu and Jiaan Shao and Jianwei Wu and Wenteng Chen and Giulianotti, {Marc A.} and Yongping Yu",

note = "Funding Information: This study was supported by the National Natural Science Foundation of China (No. 20802066 ), National Science & Technology Major Project {\textquoteleft}Key New Drug Creation and Manufacturing Program{\textquoteright} of China (No. 2009ZX09501-010 ) and the China Postdoctoral Science Foundation . We would like to give our great thanks to Mr. Jianming Gu for his help with the X-ray crystallographic analysis. ",

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doi = "10.1016/j.tet.2011.04.103",

language = "English (US)",

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T1 - A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and vinyl azides

AU - Zou, Hongbin

AU - Zhu, Huajian

AU - Shao, Jiaan

AU - Wu, Jianwei

AU - Chen, Wenteng

AU - Giulianotti, Marc A.

AU - Yu, Yongping

N1 - Funding Information: This study was supported by the National Natural Science Foundation of China (No. 20802066 ), National Science & Technology Major Project ‘Key New Drug Creation and Manufacturing Program’ of China (No. 2009ZX09501-010 ) and the China Postdoctoral Science Foundation . We would like to give our great thanks to Mr. Jianming Gu for his help with the X-ray crystallographic analysis.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - A novel and facile approach to polysubstituted pyrazoles from readily synthesized hydrazonyl chlorides and vinyl azides was developed. The reaction was regiospecific and proceeded under mild conditions in the presence of base.

AB - A novel and facile approach to polysubstituted pyrazoles from readily synthesized hydrazonyl chlorides and vinyl azides was developed. The reaction was regiospecific and proceeded under mild conditions in the presence of base.

KW - Hydrazonyl chlorides

KW - Polysubstituted pyrazoles

KW - Regiospecific approach

KW - Vinyl azides

KW - X-ray structure

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DO - 10.1016/j.tet.2011.04.103

M3 - Article

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SN - 0040-4020

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SP - 4887

EP - 4891

JO - Tetrahedron

JF - Tetrahedron

IS - 26

ER -

A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and vinyl azides

Abstract

Bibliographical note

Keywords

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