A Double-Blind, Placebo-Controlled Study of the Opiate Antagonist, Naltrexone, in the Treatment of Kleptomania

Jon E. Grant, Suck W Kim, Brian L. Odlaug

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74 Scopus citations

Abstract

Background: Kleptomania is a rare psychiatric disorder characterized by recurrent stealing and for which there exists no empirically validated treatments. This study examined the efficacy and tolerability of the opioid antagonist naltrexone in adults with kleptomania who have urges to steal. Methods: An 8-week, double-blind, placebo-controlled trial was conducted to evaluate the safety and efficacy of oral naltrexone for kleptomania. Twenty-five individuals with DSM-IV kleptomania were randomized to naltrexone (dosing ranging from 50 mg/day to 150 mg/day) or placebo. Twenty-three subjects (92%) completed the study. Subjects were assessed every 2 weeks with the Yale Brown Obsessive Compulsive Scale Modified for Kleptomania (K-YBOCS), the urge and behavior subscales of the K-YBOCS, the Kleptomania Symptom Assessment Scale (K-SAS), the Clinical Global Impressions Scale (CGI), and measures of depression, anxiety, and psychosocial functioning. Results: Subjects assigned to naltrexone had significantly greater reductions in K-YBOCS total scores (p = .001), stealing urges (p = .032), and stealing behavior (p < .001) compared with subjects on placebo. Subjects assigned to naltrexone also had greater improvement in overall kleptomania severity (reflected in the CGI scores) (p < .001). The mean effective dose of naltrexone was 116.7 (±44.4) mg/day. Conclusions: Naltrexone demonstrated statistically significant reductions in stealing urges and behavior in kleptomania. Naltrexone was well tolerated.

Original languageEnglish (US)
Pages (from-to)600-606
Number of pages7
JournalBiological psychiatry
Volume65
Issue number7
DOIs
StatePublished - Apr 1 2009

Bibliographical note

Funding Information:
Dr. Grant has received research grants from Forest Pharmaceuticals and GlaxoSmithKline. Dr. Kim and Mr. Odlaug report no biomedical financial interests or potential conflicts of interest.

Funding Information:
This research was supported in part by a Career Development Award by the National Institute of Mental Health (K23 MH069754 -01A1) to Dr. Grant. This study was supported by internal funds.

Keywords

  • Impulse control disorders
  • kleptomania
  • naltrexone
  • pharmacotherapy
  • shoplifting
  • theft

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