TY - JOUR
T1 - A double-blind, placebo-controlled crossover study investigating the effect of porcine secretin in children with autism
AU - Corbett, B.
AU - Khan, K.
AU - Czapansky-Beilman, D.
AU - Brady, N.
AU - Dropik, P.
AU - Goldman, D. Zelinsky
AU - Delaney, K.
AU - Sharp, H.
AU - Mueller, I.
AU - Shapiro, E.
AU - Ziegler, R.
PY - 2001
Y1 - 2001
N2 - Objectives: A recent patient series reported the incidental findings of improved social and language skills in 3 children with autistic spectrum disorders after the administration of secretin, a peptide hormone. However, a subsequent study did not find evidence for a drug effect. Parents are seeking treatment with secretin despite the absence of empirical investigations demonstrating amelioration in autism symptomology. In order to more precisely measure the effects of secretin, this study investigated the effect of a single intravenous dose of porcine secretin on 12 autistic children through a randomized, double-blind, placebo-controlled, crossover study. Children were assessed on objective language and on social, neuropsychological, and gastrointestinal measures to evaluate drug effects. The study was conducted over a 16-week trial. The results indicated that significant differences were not observed on the majority of the dependent variables. Statistically significant differences were observed on measures of positive affect and activity level following secretin infusion. In general, the autistic children did not demonstrate the improvements described in the initial retrospective report.
AB - Objectives: A recent patient series reported the incidental findings of improved social and language skills in 3 children with autistic spectrum disorders after the administration of secretin, a peptide hormone. However, a subsequent study did not find evidence for a drug effect. Parents are seeking treatment with secretin despite the absence of empirical investigations demonstrating amelioration in autism symptomology. In order to more precisely measure the effects of secretin, this study investigated the effect of a single intravenous dose of porcine secretin on 12 autistic children through a randomized, double-blind, placebo-controlled, crossover study. Children were assessed on objective language and on social, neuropsychological, and gastrointestinal measures to evaluate drug effects. The study was conducted over a 16-week trial. The results indicated that significant differences were not observed on the majority of the dependent variables. Statistically significant differences were observed on measures of positive affect and activity level following secretin infusion. In general, the autistic children did not demonstrate the improvements described in the initial retrospective report.
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U2 - 10.1177/000992280104000604
DO - 10.1177/000992280104000604
M3 - Article
C2 - 11824175
AN - SCOPUS:0034961354
SN - 0009-9228
VL - 40
SP - 327
EP - 331
JO - Clinical Pediatrics
JF - Clinical Pediatrics
IS - 6
ER -