A dose-response curve for the negative bias pressure of an intrathoracic pressure regulator during CPR

Charles F. Babbs, Demetris Yannopoulos

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

An intrathoracic pressure regulator (ITPR) is a device that can be added to the external end of a tracheal tube to create controlled negative airway pressure between positive pressure ventilations. The resulting downward bias of the airway pressure baseline promotes increased venous return and enhanced circulation during CPR and also during hypovolemic shock. In the present study, we exercised a mathematical model of the human cardiopulmonary system, including airways, lungs, a four chambered heart, great vessels, peripheral vascular beds, and the biomechanics of chest compression and recoil, to determine the relationship between systemic perfusion pressure during CPR and the value of baseline negative airway pressure in an ITPR. Perfusion pressure increases approximately 50% as baseline airway pressure falls from zero to -10 cm H2O. Thereafter perfusion pressure plateaus. Negative bias pressures exceeding -10 cm H2O are not needed in ITPR-CPR.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalResuscitation
Volume71
Issue number3
DOIs
StatePublished - Dec 2006

Keywords

  • ACD-CPR
  • Airway management
  • Cardiopulmonary resuscitation (CPR)
  • Coronary perfusion pressure
  • Decompression
  • Device
  • Impedance
  • Mathematical model
  • Threshold
  • Valve

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