A two-layer dissolution-diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading.
|Original language||English (US)|
|Number of pages||8|
|Journal||Journal of Biomedical Materials Research - Part B Applied Biomaterials|
|State||Published - Jul 2009|
- Drug delivery/release
- Surface characterization
- Sustained release