A decision-making tool for exchange transfusions in infants with severe hyperbilirubinemia in resource-limited settings

B. O. Olusanya, I. F. Iskander, T. M. Slusher, R. P. Wennberg

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Late presentation and ineffective phototherapy account for excessive rates of avoidable exchange transfusions (ETs) in many low-and middle-income countries. Several system-based constraints sometimes limit the ability to provide timely ETs for all infants at risk of kernicterus, thus necessitating a treatment triage to optimize available resources. This article proposes a practical priority-setting model for term and near-term infants requiring ET after the first 48 h of life. The proposed model combines plasma/serum bilirubin estimation, clinical signs of acute bilirubin encephalopathy and neurotoxicity risk factors for predicting the risk of kernicterus based on available evidence in the literature.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalJournal of Perinatology
Volume36
Issue number5
DOIs
StatePublished - May 1 2016

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