A cryptic subgroup of Anopheles gambiae is highly susceptible to human malaria parasites

Michelle M. Riehle, Wamdaogo M. Guelbeogo, Awa Gneme, Karin Eiglmeier, Inge Holm, Emmanuel Bischoff, Thierry Garnier, Gregory M. Snyder, Xuanzhong Li, Kyriacos Markianos, N'Fale Sagnon, Kenneth D. Vernick

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Population subgroups of the African malaria vector Anopheles gambiae have not been comprehensively characterized owing to the lack of unbiased sampling methods. In the arid savanna zone of West Africa, where potential oviposition sites are scarce, widespread collection from larval pools in the peridomestic human habitat yielded a comprehensive genetic survey of local A. gambiae population subgroups, independent of adult resting behavior and ecological preference. A previously unknown subgroup of exophilic A. gambiae is sympatric with the known endophilic A. gambiae in this region. The exophilic subgroup is abundant, lacks differentiation into M and S molecular forms, and is highly susceptible to infection with wild Plasmodium falciparum. These findings might have implications for the epidemiology of malaria transmission and control.

Original languageEnglish (US)
Pages (from-to)596-598
Number of pages3
JournalScience
Volume331
Issue number6017
DOIs
StatePublished - Feb 4 2011

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