A convenient orthogonally cleavable methionine handle for anchoring amines to polymeric supports

Joseph C. Kappel, George Barany

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Methionine has been used to anchor amines to polymeric supports for solid-phase synthesis. Either a "preformed handle" or a stepwise elongation strategy was followed. Cyanogen bromide (CNBr) treatment then released amines into solution. CNBr reaction variables were evaluated in order to converge to optimal cleavage conditions, and the strategy was shown to be effective for a range of primary and secondary amines, but not for aromatic amines.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalJournal of Combinatorial Chemistry
Volume7
Issue number1
DOIs
StatePublished - Jan 2005

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