A convenient method for the synthesis of N-hydroxyureas

Dennis A Parrish, Zhou Zou, C Leigh Allen, Cynthia S. Day, S Bruce King

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Treatment of amines with 1-(4-nitrophenol)-N-(O-benzylhydroxy)carbamate yields the O-benzyl protected N-hydroxyureas. Hydrogenation of the O-benzyl protected N-hydroxyureas over 5% Pd/BaSO4 cleanly gives the N-hydroxyureas in good yield. In addition to primary and secondary aliphatic and aromatic amines, this method converts amino sugars to the corresponding N-hydroxyureas without extensive protecting group chemistry.
Original languageEnglish (US)
Pages (from-to)8841-8843
JournalTetrahedron Letters
StatePublished - Nov 7 2005


  • N-Hydroxyureas
  • nitric oxide
  • nitric oxide donors
  • Carbohydrates
  • Hydrogenation


Dive into the research topics of 'A convenient method for the synthesis of N-hydroxyureas'. Together they form a unique fingerprint.

Cite this