A controlled trial comparing three treatments for chronic otitis media with effusion

G. Scott Giebink, Paul B. Batalden, Chap T Le, Frank M. Lassman, David J. Buran, Anne E. Seltz

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


A randomized, controlled clinical trial was conducted in 76 children to evaluate the efficacy of trimethoprim-sulfamethoxazole for 4 weeks, prednisone for 2 weeks and aluminum ibuprofen suspension for 2 weeks in resolving chronic otitis media with effusion which had persisted for more than 8 weeks. After 2 weeks of treatment resolution rates of chronic otitis media with effusion in the prednisone and trimethoprim-sulfamethoxazole groups were significantly greater than those in the control (no treatment) and ibuprofen groups. After 4 weeks the differences in resolution rates between the control, trimethoprim-sulfamethoxazole and prednisone groups became smaller. After 12 months of follow-up, differences in hearing sensitivity among study groups were not statistically significant, although 83% of patients had a 15-dB or greater hearing loss. Therefore short term antimicrobial and antiinflammatory treatment did not appear to have a long lasting effect on chronic middle ear inflammation.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalPediatric Infectious Disease Journal
Issue number1
StatePublished - Jan 1990


  • Ibuprofen
  • Otitis media with effusion
  • Prednisone
  • Trimethoprim-sulfamethoxazole


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