Abstract
In two collaborating hospitals, 37 depressed male and female patients were treated for four weeks in a placebo-controlled double-blind study of WIN 27,147-2. The WIN 27,147-2 group showed a statistically significant reduction in the anxious-depression factor of the Brief Psychiatric Rating Scale and the somatization factor of the Hamilton Depression Scale, plus a greater incidence of drowsiness. The placebo group showed a relatively greater improvement on the retardation scale of the Nurses Observation Scale for Inpatient Evaluation plus a greater incidence of akathisia and restlessness. These findings suggest a drug with anti-depressant anxiolytic actions with sedative properties.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 644-651 |
| Number of pages | 8 |
| Journal | Current Therapeutic Research - Clinical and Experimental |
| Volume | 22 |
| Issue number | 5 I |
| State | Published - 1977 |