A controlled study of WIN 27,147-2 in the treatment of depression

E. D. Eckert, R. Zimmermann, L. Dehnel, B. Schiele

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In two collaborating hospitals, 37 depressed male and female patients were treated for four weeks in a placebo-controlled double-blind study of WIN 27,147-2. The WIN 27,147-2 group showed a statistically significant reduction in the anxious-depression factor of the Brief Psychiatric Rating Scale and the somatization factor of the Hamilton Depression Scale, plus a greater incidence of drowsiness. The placebo group showed a relatively greater improvement on the retardation scale of the Nurses Observation Scale for Inpatient Evaluation plus a greater incidence of akathisia and restlessness. These findings suggest a drug with anti-depressant anxiolytic actions with sedative properties.

Original languageEnglish (US)
Pages (from-to)644-651
Number of pages8
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume22
Issue number5 I
StatePublished - Jan 1 1977

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