A conserved role for myosin VII in adhesion

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The class VII myosins (M7) are expressed in a wide range of organisms. M7 mutants in mice, zebrafish and Dictyostelium exhibit phenotypes that reveal a role for M7 in adhesion in these highly divergent systems, suggesting a basic conservation of M7 function throughout evolution. M7s are characterized by the presence of two FERM domains in their C-terminal tail region, and deletion of either from the Dictyostelium M7 (DdM7) tail results in loss of function without affecting localization. A search for DdM7 binding partners has revealed that talin, an actin-binding protein that provides a key link between adhesion receptors and the actin cytoskeleton, interacts directly with DdM7. The phenotypes of the DdM7 and talin null mutants are highly similar, suggesting that these two proteins work co-operatively to maintain cell-cell and cell-surface contact and that this interaction may also be conserved throughout evolution.

Original languageEnglish (US)
Title of host publicationSignalling Networks in Cell Shape and Motility
Pages16-24
Number of pages9
Volume269
StatePublished - Dec 1 2005

Publication series

NameNovartis Foundation Symposium
Volume269
ISSN (Print)1528-2511

Fingerprint

Myosins
Talin
Dictyostelium
Tail
Phenotype
Microfilament Proteins
Zebrafish
Actin Cytoskeleton
Proteins

Cite this

Titus, M. A. (2005). A conserved role for myosin VII in adhesion. In Signalling Networks in Cell Shape and Motility (Vol. 269, pp. 16-24). (Novartis Foundation Symposium; Vol. 269).

A conserved role for myosin VII in adhesion. / Titus, Margaret A.

Signalling Networks in Cell Shape and Motility. Vol. 269 2005. p. 16-24 (Novartis Foundation Symposium; Vol. 269).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Titus, MA 2005, A conserved role for myosin VII in adhesion. in Signalling Networks in Cell Shape and Motility. vol. 269, Novartis Foundation Symposium, vol. 269, pp. 16-24.
Titus MA. A conserved role for myosin VII in adhesion. In Signalling Networks in Cell Shape and Motility. Vol. 269. 2005. p. 16-24. (Novartis Foundation Symposium).
Titus, Margaret A. / A conserved role for myosin VII in adhesion. Signalling Networks in Cell Shape and Motility. Vol. 269 2005. pp. 16-24 (Novartis Foundation Symposium).
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