Abstract
(Figure Represented) An efficient synthesis of (-)-tetrahydrolipstatin (THL) is reported. This method takes advantage of a phosphate tether-mediated, one-pot, sequential RCM/CM/hydrogenation protocol to deliver THL In eight total steps from a readily prepared (S,S)-triene. The strategy incorporates selective cross-metathesis, regioselective hydrogenation, regio- and diastereoselective cuprate addition, and Mitsunobu inversion for installation of the C5 formamide ester subunit.
Original language | English (US) |
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Pages (from-to) | 1556-1559 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 12 |
Issue number | 7 |
DOIs | |
State | Published - Apr 2 2010 |
Externally published | Yes |