A concise formal total synthesis of lactimidomycin

Wei Li, Gunda Georg

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A formal total synthesis of the cytotoxic natural product lactimidomycin has been achieved in nine steps from (E)-2-methyl-2-pentenoic acid. The 12-membered lactone was efficiently formed via a copper-catalyzed ene-yne coupling/alkyne reduction tandem reaction.

Original languageEnglish (US)
Pages (from-to)8634-8636
Number of pages3
JournalChemical Communications
Issue number41
StatePublished - May 21 2015


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