Abstract
A formal total synthesis of the cytotoxic natural product lactimidomycin has been achieved in nine steps from (E)-2-methyl-2-pentenoic acid. The 12-membered lactone was efficiently formed via a copper-catalyzed ene-yne coupling/alkyne reduction tandem reaction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8634-8636 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 51 |
| Issue number | 41 |
| DOIs | |
| State | Published - May 21 2015 |
Bibliographical note
Publisher Copyright:© The Royal Society of Chemistry 2015.