A comparison study between the saturation-recovery-T1 and CASL MRI methods for quantitative CBF imaging

Xiao Wang, Xiao Hong Zhu, Yi Zhang, Afshin A. Divani, Amanda J. Murphy, Wei Chen

Research output: Contribution to journalArticle

Abstract

The saturation-recovery (SR)-T1 MRI method for quantitatively imaging cerebral blood flow (CBF) change (ΔCBF) concurrently with the blood oxygenation level dependence (BOLD) alteration has been recently developed and validated by simultaneous measurement of relative CBF change using laser Doppler flowmetry (LDF) in rats at 9.4T. In this study, ΔCBF induced by mildly transient hypercapnia and measured by the SR-T1 MRI method was rigorously compared with an established perfusion MRI method—continuous arterial spin labeling (CASL) approach in normal and preclinical middle cerebral artery occlusion (MCAo) rat models. The results show an excellent agreement between ΔCBF values measured with these two imaging methods. Moreover, the intrinsic longitudinal relaxation rate (R1 int) was experimentally determined in vivo in normal rat brains at 9.4T by comparing two independent measures of the apparent longitudinal relaxation rate (R1 app) and CBF measured by the CSAL approach across a wide range of perfusion. In turn, the R1 int constant can be employed to calculate the CBF value based on the R1 app measurement in healthy brain. This comparison study validates the fundamental relationship for linking brain tissue water R1 app and cerebral perfusion, demonstrates the feasibility of imaging and quantifying both CBF and its change using the SR-T1 MRI method in vivo.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalMagnetic Resonance Imaging
Volume37
DOIs
StatePublished - Apr 1 2017

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Cerebrovascular Circulation
Magnetic resonance imaging
Blood
Imaging techniques
Recovery
Application programs
Perfusion
Rats
Brain
Laser-Doppler Flowmetry
Hypercapnia
Middle Cerebral Artery Infarction
Oxygenation
Labeling

Keywords

  • CASL MRI
  • Cerebral blood flow
  • Middle cerebral artery occlusion
  • Perfusion
  • Rat brain
  • Saturation-recovery-T MRI

Cite this

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title = "A comparison study between the saturation-recovery-T1 and CASL MRI methods for quantitative CBF imaging",
abstract = "The saturation-recovery (SR)-T1 MRI method for quantitatively imaging cerebral blood flow (CBF) change (ΔCBF) concurrently with the blood oxygenation level dependence (BOLD) alteration has been recently developed and validated by simultaneous measurement of relative CBF change using laser Doppler flowmetry (LDF) in rats at 9.4T. In this study, ΔCBF induced by mildly transient hypercapnia and measured by the SR-T1 MRI method was rigorously compared with an established perfusion MRI method—continuous arterial spin labeling (CASL) approach in normal and preclinical middle cerebral artery occlusion (MCAo) rat models. The results show an excellent agreement between ΔCBF values measured with these two imaging methods. Moreover, the intrinsic longitudinal relaxation rate (R1 int) was experimentally determined in vivo in normal rat brains at 9.4T by comparing two independent measures of the apparent longitudinal relaxation rate (R1 app) and CBF measured by the CSAL approach across a wide range of perfusion. In turn, the R1 int constant can be employed to calculate the CBF value based on the R1 app measurement in healthy brain. This comparison study validates the fundamental relationship for linking brain tissue water R1 app and cerebral perfusion, demonstrates the feasibility of imaging and quantifying both CBF and its change using the SR-T1 MRI method in vivo.",
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author = "Xiao Wang and Zhu, {Xiao Hong} and Yi Zhang and Divani, {Afshin A.} and Murphy, {Amanda J.} and Wei Chen",
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AU - Wang, Xiao

AU - Zhu, Xiao Hong

AU - Zhang, Yi

AU - Divani, Afshin A.

AU - Murphy, Amanda J.

AU - Chen, Wei

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AB - The saturation-recovery (SR)-T1 MRI method for quantitatively imaging cerebral blood flow (CBF) change (ΔCBF) concurrently with the blood oxygenation level dependence (BOLD) alteration has been recently developed and validated by simultaneous measurement of relative CBF change using laser Doppler flowmetry (LDF) in rats at 9.4T. In this study, ΔCBF induced by mildly transient hypercapnia and measured by the SR-T1 MRI method was rigorously compared with an established perfusion MRI method—continuous arterial spin labeling (CASL) approach in normal and preclinical middle cerebral artery occlusion (MCAo) rat models. The results show an excellent agreement between ΔCBF values measured with these two imaging methods. Moreover, the intrinsic longitudinal relaxation rate (R1 int) was experimentally determined in vivo in normal rat brains at 9.4T by comparing two independent measures of the apparent longitudinal relaxation rate (R1 app) and CBF measured by the CSAL approach across a wide range of perfusion. In turn, the R1 int constant can be employed to calculate the CBF value based on the R1 app measurement in healthy brain. This comparison study validates the fundamental relationship for linking brain tissue water R1 app and cerebral perfusion, demonstrates the feasibility of imaging and quantifying both CBF and its change using the SR-T1 MRI method in vivo.

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