A comparison of the effects of corticotropin releasing factor and sauvagine on food intake

Blake A Gosnell; John E. Morley; Allen S Levine

doi:10.1016/0091-3057(83)90078-3

A comparison of the effects of corticotropin releasing factor and sauvagine on food intake

Blake A Gosnell, John E. Morley, Allen S Levine

Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Corticotropin releasing factor (CRF) and sauvagine (SVG) when administered ICV both reduced spontaneous feeding as well as feeding induced by deprivation or the administration of ethylketocyclazocine (EKC). For spontaneous- and EKC-induced feeding, SVG produced a larger and longer-lasting suppressive effect than did CRF. Both peptides produced a conditioned taste aversion when paired with a novel saccharin taste. As with the feeding effects, SVG produced a stronger aversion than CRF. These studies further establish the similarity between CRF and SVG and suggest that they may have a disruptive effect on feeding.

Original language	English (US)
Pages (from-to)	771-775
Number of pages	5
Journal	Pharmacology, Biochemistry and Behavior
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(83)90078-3
State	Published - Nov 1983

Keywords

Corticotropin releasing factor
Food intake
Sauvagine

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10.1016/0091-3057(83)90078-3

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abstract = "Corticotropin releasing factor (CRF) and sauvagine (SVG) when administered ICV both reduced spontaneous feeding as well as feeding induced by deprivation or the administration of ethylketocyclazocine (EKC). For spontaneous- and EKC-induced feeding, SVG produced a larger and longer-lasting suppressive effect than did CRF. Both peptides produced a conditioned taste aversion when paired with a novel saccharin taste. As with the feeding effects, SVG produced a stronger aversion than CRF. These studies further establish the similarity between CRF and SVG and suggest that they may have a disruptive effect on feeding.",

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AU - Gosnell, Blake A

AU - Morley, John E.

AU - Levine, Allen S

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N2 - Corticotropin releasing factor (CRF) and sauvagine (SVG) when administered ICV both reduced spontaneous feeding as well as feeding induced by deprivation or the administration of ethylketocyclazocine (EKC). For spontaneous- and EKC-induced feeding, SVG produced a larger and longer-lasting suppressive effect than did CRF. Both peptides produced a conditioned taste aversion when paired with a novel saccharin taste. As with the feeding effects, SVG produced a stronger aversion than CRF. These studies further establish the similarity between CRF and SVG and suggest that they may have a disruptive effect on feeding.

AB - Corticotropin releasing factor (CRF) and sauvagine (SVG) when administered ICV both reduced spontaneous feeding as well as feeding induced by deprivation or the administration of ethylketocyclazocine (EKC). For spontaneous- and EKC-induced feeding, SVG produced a larger and longer-lasting suppressive effect than did CRF. Both peptides produced a conditioned taste aversion when paired with a novel saccharin taste. As with the feeding effects, SVG produced a stronger aversion than CRF. These studies further establish the similarity between CRF and SVG and suggest that they may have a disruptive effect on feeding.

KW - Corticotropin releasing factor

KW - Food intake

KW - Sauvagine

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A comparison of the effects of corticotropin releasing factor and sauvagine on food intake

Abstract

Keywords

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