TY - JOUR
T1 - A comparison of kidney disease in type I and type II diabetes.
AU - Mauer, S. M.
AU - Chavers, Blanche M
PY - 1985
Y1 - 1985
N2 - Diabetes is the most important cause of ESRD in the Western world. Type I and II diabetes appear to contribute importantly to ESRD although, obviously, the prevalence of ESRD is higher in Type I. Microalbuminuria may predict later development of overt clinical nephropathy in both Type I and Type II patients. In both diabetes subtypes current evidence favours the dysmetabolism of diabetes as causative. There are clinical observations in Type I and renal morphologic evidence in Type II indicating that risk of nephropathy is, in part, related to the magnitude of hyperglycemia. Institution of strict glycemic control fails to reverse established clinical nephropathy in Type I diabetes. Efforts to determine if precise regulation of blood sugar can prevent nephropathy in patients with Type I and Type II diabetes are currently incomplete.
AB - Diabetes is the most important cause of ESRD in the Western world. Type I and II diabetes appear to contribute importantly to ESRD although, obviously, the prevalence of ESRD is higher in Type I. Microalbuminuria may predict later development of overt clinical nephropathy in both Type I and Type II patients. In both diabetes subtypes current evidence favours the dysmetabolism of diabetes as causative. There are clinical observations in Type I and renal morphologic evidence in Type II indicating that risk of nephropathy is, in part, related to the magnitude of hyperglycemia. Institution of strict glycemic control fails to reverse established clinical nephropathy in Type I diabetes. Efforts to determine if precise regulation of blood sugar can prevent nephropathy in patients with Type I and Type II diabetes are currently incomplete.
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U2 - 10.1007/978-1-4757-1850-8_16
DO - 10.1007/978-1-4757-1850-8_16
M3 - Article
C2 - 4036716
AN - SCOPUS:0021780712
SN - 0065-2598
VL - 189
SP - 299
EP - 303
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -