A comparison of genetic variants between proficient low- and high-risk sport participants

Cynthia J. Thomson, Rebecca J. Power, Scott R Carlson, Jim L. Rupert, Grégory Michel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Abstract: Athletes participating in high-risk sports consistently report higher scores on sensation-seeking measures than do low-risk athletes or non-athletic controls. To determine whether genetic variants commonly associated with sensation seeking were over-represented in such athletes, proficient practitioners of high-risk (n = 141) and low-risk sports (n = 132) were compared for scores on sensation seeking and then genotyped at 33 polymorphic loci in 14 candidate genes. As expected, athletes participating in high-risk sports score higher on sensation seeking than did low-risk sport athletes (P < .01). Genotypes were associated with high-risk sport participation for two genes (stathmin, (P = .004) and brain-derived neurotrophic factor (P = .03)) as well as when demographically matched subsets of the sport cohorts were compared (P < .05); however, in all cases, associations did not survive correction for multiple testing.

Original languageEnglish (US)
Pages (from-to)1861-1870
Number of pages10
JournalJournal of Sports Sciences
Volume33
Issue number18
DOIs
StatePublished - Nov 8 2015

Keywords

  • BDNF
  • genetics
  • reward
  • risk-taking sport
  • sensation seeking
  • stathmin

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