The purpose of this study was to investigate the relationships among peak exercise parameters on 6-min walk test, shuttle walk test, and laboratory-based cardiopulmonary exercise testing in persons with Alzheimer’s dementia. This study is a cross-sectional analysis of the baseline data of 90 participants (age 77.1 [6.6] years, 43% female) from the FIT-AD trial. Cardiopulmonary exercise testing produced significantly higher peak heart rate (118.6 [17.5] vs. 106 [22.8] vs. 106 [18.8] beats/min), rating of perceived exertion (16 [2.1] vs. 12 [2.3] vs. 11 [2.1]), and systolic blood pressure (182 [23.7] vs. 156 [18.9] vs. 150 [16.9] mmHg) compared with the shuttle walk test and 6-min walk test, respectively. Peak walking distance on shuttle walk test (241.3 [127.3] m) and 6-min walk test (365.0 [107.9] m) significantly correlated with peak oxygen consumption (17.1 [4.3] ml·kg−1·min−1) on cardiopulmonary exercise testing (r = .449, p ≤ .001 and r = .435, p ≤ .001), respectively, which is considerably lower than what is seen in older adults and persons with cardiopulmonary diseases.
Bibliographical noteFunding Information:
The study was funded by the National Institute on Aging of the National Institutes of Health Award Number 1R01AG043392-01A1. All subject interviews and data collections occurred at the CTSI that was supported by the National Institutes of Health National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114. The authors have no conflicts of interest to disclose. The results of the study have not been published elsewhere nor have been submitted simultaneously for publication elsewhere. The results within are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. The content within is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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- 6-min walk test
- Aerobic fitness
- Cognitive impairment
- Graded exercise test
- Shuttle walk test