An empirical comparison of existing algorithms for the computer generation of exact D-optimal experimental designs is carried out. Among algorithms considered were those due to Wyrnn, Mitchell, Fedorov, and Van Schalkwyk. A procedure for rounding off approximate designs as suggested by Kiefer is also evaluated. A modification of the Fedorov algorithm is given and shown to effect substantial decreases in the computer time required for design generation.
Bibliographical noteFunding Information:
R. D. Cook is a Visiting Staff Member of the Los Alamos Scientific Laboratory. This work was partially performed under the auspices of the United States Department of Energy (Contract W-7405 ENG.36).
- Computer search
- Exchange algorithm
- Mixture designs
- Optimal designs