A comparative study of proteomics maps using graph theoretical biodescriptors

Milan Randić, Subhash C. Basak

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

This paper reports the development of new methods for mathematical characterization of effects of different toxic agents on the cellular proteome. We describe numerical characterization of proteomics maps based on mathematical invariants. A graph is first associated with a proteomics map by considering partial ordering of spots on 2-D gels by ordering proteins with respect to the mass and the charge, the two properties by which proteins are separated. The graph is then embedded over the map, and several graph theoretical invariants have been constructed. In particular we consider invariants that can be extracted from the Euclidean distance-adjacency matrix of the embedded graph, in which only Euclidean distances between adjacent vertices of a graph are considered. The approach is illustrated using proteomics patterns of normal liver cells of rats and those derived from liver cells of animals exposed to four peroxisome proliferators. In contrast to direct comparison of spot abundance our approach incorporates information on spots locations. The difference between the two approaches is that in the first case only changes in abundances are considered as a measure of perturbation of the proteome map, but in the second case not only the charge but also the mass of proteins are used for ordering protein spots.

Original languageEnglish (US)
Pages (from-to)983-992
Number of pages10
JournalJournal of chemical information and computer sciences
Volume42
Issue number5
DOIs
StatePublished - Sep 2002
Externally publishedYes

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