A Comparative Review of Vitamin E and Associated Equine Disorders

C. J. Finno, S. J. Valberg

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Vitamin E is a primary chain-breaking antioxidant that prevents cyclic propagation of lipid peroxidation. Across species, vitamin E is essential for normal neuromuscular function by acting as a potent antioxidant, as well as by modulating the expression of certain genes, inhibiting platelet aggregation and stabilizing plasma membranes. This review focuses on vitamin E structure, absorption, metabolism, current equine dietary recommendations, the interplay between antioxidants and exercise, a discussion of the necessity of vitamin E supplementation in the horse above the Nutritional Research Council (NRC) 2007 requirements, and a review of equine diseases that are associated with a vitamin E deficiency. Particular emphasis is placed on the proteins involved in vitamin E absorption, transport, and metabolism as potential candidates for vitamin E-associated diseases across species.

Original languageEnglish (US)
Pages (from-to)1251-1266
Number of pages16
JournalJournal of veterinary internal medicine
Volume26
Issue number6
DOIs
StatePublished - 2012

Keywords

  • Genetics
  • Neurology
  • Neuromuscular disorders
  • Nutrition
  • Spinal cord disease

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