Abstract
Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 457-463 |
| Number of pages | 7 |
| Journal | Nature |
| Volume | 551 |
| Issue number | 7681 |
| DOIs | |
| State | Published - Nov 23 2017 |
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A communal catalogue reveals Earth's multiscale microbial diversity. / Thompson, Luke R.; Sanders, Jon G.; McDonald, Daniel; Amir, Amnon; Ladau, Joshua; Locey, Kenneth J.; Prill, Robert J.; Tripathi, Anupriya; Gibbons, Sean M.; Ackermann, Gail; Navas-Molina, Jose A.; Janssen, Stefan; Kopylova, Evguenia; Vázquez-Baeza, Yoshiki; González, Antonio; Morton, James T.; Mirarab, Siavash; Xu, Zhenjiang Zech; Jiang, Lingjing; Haroon, Mohamed F.; Kanbar, Jad; Zhu, Qiyun; Song, Se Jin; Kosciolek, Tomasz; Bokulich, Nicholas A.; Lefler, Joshua; Brislawn, Colin J.; Humphrey, Gregory; Owens, Sarah M.; Hampton-Marcell, Jarrad; Berg-Lyons, Donna; McKenzie, Valerie; Fierer, Noah; Fuhrman, Jed A.; Clauset, Aaron; Stevens, Rick L.; Shade, Ashley; Pollard, Katherine S.; Goodwin, Kelly D.; Jansson, Janet K.; Gilbert, Jack A.; Knight, Rob; Agosto Rivera, Jose L.; Al-Moosawi, Lisa; Alverdy, John; Amato, Katherine R.; Andras, Jason; Angenent, Largus T.; Antonopoulos, Dionysios A.; Clayton, Jonathan B.; Earth Microbiome Project Consortium.
In: Nature, Vol. 551, No. 7681, 23.11.2017, p. 457-463.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A communal catalogue reveals Earth's multiscale microbial diversity
AU - Thompson, Luke R.
AU - Sanders, Jon G.
AU - McDonald, Daniel
AU - Amir, Amnon
AU - Ladau, Joshua
AU - Locey, Kenneth J.
AU - Prill, Robert J.
AU - Tripathi, Anupriya
AU - Gibbons, Sean M.
AU - Ackermann, Gail
AU - Navas-Molina, Jose A.
AU - Janssen, Stefan
AU - Kopylova, Evguenia
AU - Vázquez-Baeza, Yoshiki
AU - González, Antonio
AU - Morton, James T.
AU - Mirarab, Siavash
AU - Xu, Zhenjiang Zech
AU - Jiang, Lingjing
AU - Haroon, Mohamed F.
AU - Kanbar, Jad
AU - Zhu, Qiyun
AU - Song, Se Jin
AU - Kosciolek, Tomasz
AU - Bokulich, Nicholas A.
AU - Lefler, Joshua
AU - Brislawn, Colin J.
AU - Humphrey, Gregory
AU - Owens, Sarah M.
AU - Hampton-Marcell, Jarrad
AU - Berg-Lyons, Donna
AU - McKenzie, Valerie
AU - Fierer, Noah
AU - Fuhrman, Jed A.
AU - Clauset, Aaron
AU - Stevens, Rick L.
AU - Shade, Ashley
AU - Pollard, Katherine S.
AU - Goodwin, Kelly D.
AU - Jansson, Janet K.
AU - Gilbert, Jack A.
AU - Knight, Rob
AU - Agosto Rivera, Jose L.
AU - Al-Moosawi, Lisa
AU - Alverdy, John
AU - Amato, Katherine R.
AU - Andras, Jason
AU - Angenent, Largus T.
AU - Antonopoulos, Dionysios A.
AU - Clayton, Jonathan B.
AU - Earth Microbiome Project Consortium
PY - 2017/11/23
Y1 - 2017/11/23
N2 - Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.
AB - Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.
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UR - http://www.scopus.com/inward/citedby.url?scp=85034804875&partnerID=8YFLogxK
U2 - 10.1038/nature24621
DO - 10.1038/nature24621
M3 - Article
VL - 551
SP - 457
EP - 463
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7681
ER -