TY - JOUR
T1 - A closer look at the structure of sterically stabilized liposomes
T2 - A small-angle x-ray scattering study
AU - Varga, Zoltán
AU - Berényi, Szilvia
AU - Szokol, Bálint
AU - O'rfi, László
AU - Kéri, György
AU - Peták, István
AU - Hoell, Armin
AU - Bóta, Attila
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2010/5/27
Y1 - 2010/5/27
N2 - The evaluation of the radial electron density profile of a drug containing a sterically stabilized liposomal system is described. Using synchrotron small-angle X-ray scattering, we were able to characterize the hydrophilic shell of the polyethylene glycol chains. Using a Gaussian model for describing the electron density profile along the normal of the bilayer, we got an asymmetric distribution of PEGylated lipids in accordance with theoretical considerations. Moreover, we used anomalous X-ray scattering to study the localization of a hydrophobic drug (a kinase inhibitor), which revealed that these molecules are mainly located in the hydrocarbon chain region of the phospholipid bilayer.
AB - The evaluation of the radial electron density profile of a drug containing a sterically stabilized liposomal system is described. Using synchrotron small-angle X-ray scattering, we were able to characterize the hydrophilic shell of the polyethylene glycol chains. Using a Gaussian model for describing the electron density profile along the normal of the bilayer, we got an asymmetric distribution of PEGylated lipids in accordance with theoretical considerations. Moreover, we used anomalous X-ray scattering to study the localization of a hydrophobic drug (a kinase inhibitor), which revealed that these molecules are mainly located in the hydrocarbon chain region of the phospholipid bilayer.
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U2 - 10.1021/jp9109207
DO - 10.1021/jp9109207
M3 - Article
C2 - 20429570
AN - SCOPUS:77952725708
VL - 114
SP - 6850
EP - 6854
JO - Journal of Physical Chemistry B
JF - Journal of Physical Chemistry B
SN - 1520-6106
IS - 20
ER -