A closer look at the structure of sterically stabilized liposomes: A small-angle x-ray scattering study

Zoltán Varga; Szilvia Berényi; Bálint Szokol; László O'rfi; György Kéri; István Peták; Armin Hoell; Attila Bóta

doi:10.1021/jp9109207

A closer look at the structure of sterically stabilized liposomes: A small-angle x-ray scattering study

Zoltán Varga, Szilvia Berényi, Bálint Szokol, László O'rfi, György Kéri, István Peták, Armin Hoell, Attila Bóta

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Abstract

The evaluation of the radial electron density profile of a drug containing a sterically stabilized liposomal system is described. Using synchrotron small-angle X-ray scattering, we were able to characterize the hydrophilic shell of the polyethylene glycol chains. Using a Gaussian model for describing the electron density profile along the normal of the bilayer, we got an asymmetric distribution of PEGylated lipids in accordance with theoretical considerations. Moreover, we used anomalous X-ray scattering to study the localization of a hydrophobic drug (a kinase inhibitor), which revealed that these molecules are mainly located in the hydrocarbon chain region of the phospholipid bilayer.

Original language	English (US)
Pages (from-to)	6850-6854
Number of pages	5
Journal	Journal of Physical Chemistry B
Volume	114
Issue number	20
DOIs	https://doi.org/10.1021/jp9109207
State	Published - May 27 2010
Externally published	Yes

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10.1021/jp9109207

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A closer look at the structure of sterically stabilized liposomes : A small-angle x-ray scattering study. / Varga, Zoltán; Berényi, Szilvia; Szokol, Bálint; O'rfi, László; Kéri, György; Peták, István; Hoell, Armin; Bóta, Attila.

In: Journal of Physical Chemistry B, Vol. 114, No. 20, 27.05.2010, p. 6850-6854.

Research output: Contribution to journal › Article › peer-review

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AU - O'rfi, László

AU - Kéri, György

AU - Peták, István

AU - Hoell, Armin

AU - Bóta, Attila

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A closer look at the structure of sterically stabilized liposomes: A small-angle x-ray scattering study

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