A classification system for tableting behaviors of binary powder mixtures

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Abstract

The ability to predict tableting properties of a powder mixture from individual components is of both fundamental and practical importance to the efficient formulation development of tablet products. A common tableting classification system (TCS) of binary powder mixtures facilitates the systematic development of new knowledge in this direction. Based on the dependence of tablet tensile strength on weight fraction in a binary mixture, three main types of tableting behavior are identified. Each type is further divided to arrive at a total of 15 sub-classes. The proposed classification system lays a framework for a better understanding of powder interactions during compaction. Potential applications and limitations of this classification system are discussed.

Original languageEnglish (US)
Pages (from-to)486-491
Number of pages6
JournalAsian Journal of Pharmaceutical Sciences
Volume11
Issue number4
DOIs
StatePublished - Aug 1 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author.

Keywords

  • Classification system
  • Compaction
  • Mixture
  • Powder
  • Tabletability
  • Tensile strength

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