A case of opsoclonus-myoclonus syndrome associated with breast cancer

Sebastian Mohar; Naomi Fujioka; Todd Tuttle; Bruce Trautman; Emilian Racila; Jianling Yuan; Sean J. Pittock; David A Potter

doi:10.1016/j.cpccr.2024.100346

A case of opsoclonus-myoclonus syndrome associated with breast cancer

Sebastian Mohar, Naomi Fujioka, Todd Tuttle, Bruce Trautman, Emilian Racila, Jianling Yuan, Sean J. Pittock, David A Potter

Research output: Contribution to journal › Article › peer-review

Abstract

Opsoclonus-myoclonus syndrome (OMS) is a rare presenting complication of cancer that is thought to be related to autoimmune mediated perturbation of homeostasis of oculomotor and limb movement. Symptoms can include arrhythmic conjugate saccades of the eyes without interval and involuntary movements of the limbs. The patient was a 56-year-old woman with OMS and an occult axillary cT0N1M0 triple negative breast cancer (TNBC). She had negative serum and CSF serology. She was initially treated with steroids and immune globulin and then neoadjuvant chemotherapy. She underwent surgical excision and radiation. At 9 years the patient is without recurrence of OMS or TNBC.

Original language	English (US)
Article number	100346
Journal	Current Problems in Cancer: Case Reports
Volume	17
DOIs	https://doi.org/10.1016/j.cpccr.2024.100346
State	Published - Mar 2025

Bibliographical note

Publisher Copyright:
© 2024 The Author(s)

Keywords

Breast cancer
Inflammation
Opsoclonus myoclonus syndrome
Paraneoplastic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cpccr.2024.100346

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title = "A case of opsoclonus-myoclonus syndrome associated with breast cancer",

abstract = "Opsoclonus-myoclonus syndrome (OMS) is a rare presenting complication of cancer that is thought to be related to autoimmune mediated perturbation of homeostasis of oculomotor and limb movement. Symptoms can include arrhythmic conjugate saccades of the eyes without interval and involuntary movements of the limbs. The patient was a 56-year-old woman with OMS and an occult axillary cT0N1M0 triple negative breast cancer (TNBC). She had negative serum and CSF serology. She was initially treated with steroids and immune globulin and then neoadjuvant chemotherapy. She underwent surgical excision and radiation. At 9 years the patient is without recurrence of OMS or TNBC.",

keywords = "Breast cancer, Inflammation, Opsoclonus myoclonus syndrome, Paraneoplastic",

author = "Sebastian Mohar and Naomi Fujioka and Todd Tuttle and Bruce Trautman and Emilian Racila and Jianling Yuan and Pittock, {Sean J.} and Potter, {David A}",

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doi = "10.1016/j.cpccr.2024.100346",

language = "English (US)",

volume = "17",

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AU - Mohar, Sebastian

AU - Fujioka, Naomi

AU - Tuttle, Todd

AU - Trautman, Bruce

AU - Racila, Emilian

AU - Yuan, Jianling

AU - Pittock, Sean J.

AU - Potter, David A

PY - 2025/3

Y1 - 2025/3

N2 - Opsoclonus-myoclonus syndrome (OMS) is a rare presenting complication of cancer that is thought to be related to autoimmune mediated perturbation of homeostasis of oculomotor and limb movement. Symptoms can include arrhythmic conjugate saccades of the eyes without interval and involuntary movements of the limbs. The patient was a 56-year-old woman with OMS and an occult axillary cT0N1M0 triple negative breast cancer (TNBC). She had negative serum and CSF serology. She was initially treated with steroids and immune globulin and then neoadjuvant chemotherapy. She underwent surgical excision and radiation. At 9 years the patient is without recurrence of OMS or TNBC.

AB - Opsoclonus-myoclonus syndrome (OMS) is a rare presenting complication of cancer that is thought to be related to autoimmune mediated perturbation of homeostasis of oculomotor and limb movement. Symptoms can include arrhythmic conjugate saccades of the eyes without interval and involuntary movements of the limbs. The patient was a 56-year-old woman with OMS and an occult axillary cT0N1M0 triple negative breast cancer (TNBC). She had negative serum and CSF serology. She was initially treated with steroids and immune globulin and then neoadjuvant chemotherapy. She underwent surgical excision and radiation. At 9 years the patient is without recurrence of OMS or TNBC.

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KW - Inflammation

KW - Opsoclonus myoclonus syndrome

KW - Paraneoplastic

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A case of opsoclonus-myoclonus syndrome associated with breast cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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