A case-control study provides evidence of association for a common SNP rs974819 in PDGFD to coronary heart disease and suggests a sex-dependent effect

Jianqing Zhou, Yi Huang, R. Stephanie Huang, Feiming Wang, Limin Xu, Yanping Le, Xi Yang, Weifeng Xu, Xiaoyan Huang, Jiangfang Lian, Shiwei Duan

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Introduction: Peden et al. have revealed a significant association between four new risk loci and coronary heart disease (CHD) in Europeans and South Asians. The goal of this study is to evaluate the contribution of these genetic loci to CHD risk in Han Chinese. Methods: We recruited 161 CHD patients and 112 controls proved by angiography originated from Ningbo in the Eastern China, and performed a case-control association study of the four significant SNPs. Results: Among the four tested SNPs, we found a significant association of rs974819 in PDGFD gene with CHD (allele p = 0.04; OR = 1.45, 95% CI = 1.02 - 2.08) and the allele A/G of rs974819 shows significant difference in females (allele p = 0.04; OR = 1.83, 95% CI = 1.01 - 3.31). A further meta-analysis showed that rs974819 of PDGFD gene was significantly associated with an increasing risk of CHD (OR = 1.08, 95% CI = 1.05 - 1.11) in both Europeans and South Asians including Han Chinese. Conclusions: Our findings suggests that rs974819 of PDGFD is also a CHD risk factor in Han Chinese. In addition, it presents a sex-dependent genetic effect.

Original languageEnglish (US)
Pages (from-to)602-606
Number of pages5
JournalThrombosis Research
Volume130
Issue number4
DOIs
StatePublished - Oct 2012

Bibliographical note

Funding Information:
The research was supported by the grants from: National Natural Science Foundation of China (31100919 and 30772155), Qianjiang Scholars Foundation of Zhejiang Province, Zhejiang Provincial Program for the Cultivation of High1level Innovative Health Talents, Natural Science Foundation of Zhejiang Province (Y206608), the K.C. Wong Education Foundation, Hong Kong, the Scientific Innovation Team Project of Ningbo (No.2011B82014), and Youth and Doctor Foundation of Ningbo (2005A610016).

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

  • ADAMTS7
  • BCAP29
  • Coronary heart disease
  • LIPA
  • PDGFD
  • SNP

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