A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses

M. Ciocca; S. Marcozzi; P. Mariani; V. Lacconi; A. Di Carlo; L. Cinà; M. D. Rosato-Siri; A. Zanon; G. Cattelan; E. Avancini; P. Lugli; S. Priya; A. Camaioni; T. M. Brown

doi:10.1109/NMDC57951.2023.10344066

A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses

M. Ciocca, S. Marcozzi, P. Mariani, V. Lacconi, A. Di Carlo, L. Cinà, M. D. Rosato-Siri, A. Zanon, G. Cattelan, E. Avancini, P. Lugli, S. Priya, A. Camaioni, T. M. Brown

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Organic semiconductors are promising for interfacing with biological systems because they are biocompatible, printable and their optical properties tuned. We developed a bio-photoelectrolytic platform based on semiconducting polymer thin films, onto which neuroblastoma SH-SY5Y cells were cultured immersing both in an aqueous biological medium. It was possible to inhibit cell proliferation by 50% in this cancer cell line by subjecting the platform to a series of light pulses over time. Light stimulation was found to increase the concentration of calcium ions inside the cells by three times. The platform also enabled to measure bio-electrical signals. The bio-photoelectrolytic platform and the effective use of light stimulation may open new avenues for in vitro light control/manipulation of cell behaviour, for the development of future novel non-invasive tools for application in biosensing, regenerative medicine and cell-based therapy, and for cancer progression control and therapy.

Original language	English (US)
Title of host publication	2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	527-528
Number of pages	2
ISBN (Electronic)	9798350335460
DOIs	https://doi.org/10.1109/NMDC57951.2023.10344066
State	Published - 2023
Externally published	Yes
Event	18th IEEE Nanotechnology Materials and Devices Conference, NMDC 2023 - Paestum, Italy Duration: Oct 22 2023 → Oct 25 2023

Publication series

Name	2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023

Conference

Conference	18th IEEE Nanotechnology Materials and Devices Conference, NMDC 2023
Country/Territory	Italy
City	Paestum
Period	10/22/23 → 10/25/23

Bibliographical note

Publisher Copyright:
© 2023 IEEE.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/NMDC57951.2023.10344066

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Ciocca, M., Marcozzi, S., Mariani, P., Lacconi, V., Carlo, A. D., Cinà, L., Rosato-Siri, M. D., Zanon, A., Cattelan, G., Avancini, E., Lugli, P., Priya, S., Camaioni, A., & Brown, T. M. (2023). A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses. In 2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023 (pp. 527-528). (2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NMDC57951.2023.10344066

A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses. / Ciocca, M.; Marcozzi, S.; Mariani, P. et al.
2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023. Institute of Electrical and Electronics Engineers Inc., 2023. p. 527-528 (2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ciocca, M, Marcozzi, S, Mariani, P, Lacconi, V, Carlo, AD, Cinà, L, Rosato-Siri, MD, Zanon, A, Cattelan, G, Avancini, E, Lugli, P, Priya, S, Camaioni, A & Brown, TM 2023, A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses. in 2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023. 2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023, Institute of Electrical and Electronics Engineers Inc., pp. 527-528, 18th IEEE Nanotechnology Materials and Devices Conference, NMDC 2023, Paestum, Italy, 10/22/23. https://doi.org/10.1109/NMDC57951.2023.10344066

Ciocca M, Marcozzi S, Mariani P, Lacconi V, Carlo AD, Cinà L et al. A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses. In 2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023. Institute of Electrical and Electronics Engineers Inc. 2023. p. 527-528. (2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023). doi: 10.1109/NMDC57951.2023.10344066

Ciocca, M. ; Marcozzi, S. ; Mariani, P. et al. / A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses. 2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023. Institute of Electrical and Electronics Engineers Inc., 2023. pp. 527-528 (2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023).

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AB - Organic semiconductors are promising for interfacing with biological systems because they are biocompatible, printable and their optical properties tuned. We developed a bio-photoelectrolytic platform based on semiconducting polymer thin films, onto which neuroblastoma SH-SY5Y cells were cultured immersing both in an aqueous biological medium. It was possible to inhibit cell proliferation by 50% in this cancer cell line by subjecting the platform to a series of light pulses over time. Light stimulation was found to increase the concentration of calcium ions inside the cells by three times. The platform also enabled to measure bio-electrical signals. The bio-photoelectrolytic platform and the effective use of light stimulation may open new avenues for in vitro light control/manipulation of cell behaviour, for the development of future novel non-invasive tools for application in biosensing, regenerative medicine and cell-based therapy, and for cancer progression control and therapy.

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A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses

Abstract

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Bibliographical note

UN SDGs

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